Desflurane-induced post-conditioning against myocardial infarction is mediated by calcium-activated potassium channels: role of the mitochondrial permeability.

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Desflurane-induced post-conditioning against myocardial infarction is mediated by calcium-activated potassium channels: role of the mitochondrial permeability transition pore J. Stumpner, M. Lange, A. Beck, T.M. Smul, C.A. Lotz, F. Kehl, N. Roewer, A. Redel British Journal of Anaesthesia Volume 108, Issue 4, Pages 594-601 (April 2012) DOI: 10.1093/bja/aer496 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Schematic diagram illustrating the experimental protocol. All mice underwent 45 min of CAO followed by 3 h reperfusion. Mice received either no intervention (CON), DMSO, DES, BKCa activator NS1619 (NS1619) alone or in combination with DES (DES+NS1619), and BKCa inhibitor iberiotoxin (IbTx) alone or in combination with DES (DES+IbTx). To investigate the role of the mPTP, mice received mPTP opener atractyloside (ATRA) alone or in combination with DES (DES+ATRA), and mPTP inhibitor CYC A alone or in combination with DES (DES+CYC A). A possible interaction of BKCa and mPTP was revealed by combining mPTP opener atractyloside and BKCa activator NS1619 (NS1619+ATRA) and mPTP inhibitor CYC A and BKCa inhibitor iberiotoxin (IbTx+CYC A), respectively. Additionally, mice received ROS scavenger NAC either alone (NAC) or in combination with atractyloside and NS1619 (NS1619+ATRA+NAC). British Journal of Anaesthesia 2012 108, 594-601DOI: (10.1093/bja/aer496) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 Myocardial IS expressed as percentage of left ventricular AAR. Data are mean (sd). n=7 (n=6 in the NAC group) in each group. *Significantly (P<0.05) different from CON. #Significantly (P<0.05) different from DES. ‡Significantly different from ATRA. ∫Significantly (P<0.05) different from NS1619. ╪Significantly (P<0.05) different from IbTx. †Significantly different from NS1619+ATRA. CON, control; DMSO, dimethylsulphoxide; DES, desflurane; IbTx, iberiotoxin; ATRA, atractyloside; CYC A, cyclosporine A; NAC, N-acetylcysteine. British Journal of Anaesthesia 2012 108, 594-601DOI: (10.1093/bja/aer496) Copyright © 2012 The Author(s) Terms and Conditions