*P < 0.01; †P < The experiments were repeated 5 times.

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Cockroach proteases increase IL-8 expression in human bronchial epithelial cells via activation of protease-activated receptor (PAR)–2 and extracellular-signal-regulated.
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*P < 0.01; †P < The experiments were repeated 5 times.
*P < 0.01 and †P < The experiments were repeated 6 times.
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*P < 0.05; †P < The experiments were repeated 5 times.
*P < The experiments were repeated 5 times.
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*P < 0.01; †P < 0.001. The experiments were repeated 5 times. Fig. 4. GCE significantly suppresses GSTP1 expression in a mouse model. GSTP1 expression is significantly increased by PAR2-ant and NAC treatment in the lung, as indicated by immunohistopathology (immunohistochemistry, 200 × magnification) (A) and intensity quantification (B). GCE, German cockroach extract; GSTP1, glutathione S-transferase 1; NAC, N-acetylcysteine; PAR2-ant, protease-activated receptor 2-antagonist. *P < 0.01; †P < 0.001. The experiments were repeated 5 times. Fig. 4. GCE significantly suppresses GSTP1 expression in a mouse model. GSTP1 expression is significantly increased by PAR2- ant and NAC treatment in the lung, as indicated by immunohistopathology (immunohistochemistry, 200 × magnification) (A) and intensity quantification (B). GCE, German cockroach extract; GSTP1, glutathione S-transferase 1; NAC, N-acetylcysteine… Allergy Asthma Immunol Res. 2019 Jul;11(4):560-571. https://doi.org/10.4168/aair.2019.11.4.560