*P < 0.01; †P < The experiments were repeated 5 times.

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*P < 0.01; †P < 0.001. The experiments were repeated 5 times. Fig. 6. GCE significantly disturbs claudin-1 expression in a mouse model. Claudin-1 expression is significantly restored by PAR2-ant and NAC treatment in the lung, as indicated by immunohistochemistry (200 × magnification) (A) and intensity quantification (B). GCE, German cockroach extract; PAR2-ant, protease-activated receptor 2-antagonist; NAC, N-acetylcysteine. *P < 0.01; †P < 0.001. The experiments were repeated 5 times. Fig. 6. GCE significantly disturbs claudin-1 expression in a mouse model. Claudin-1 expression is significantly restored by PAR2- ant and NAC treatment in the lung, as indicated by immunohistochemistry (200 × magnification) (A) and intensity quantification (B). GCE, German cockroach extract; PAR2-ant, protease-activated receptor 2-antagonist; NAC, N-acetylcysteine… Allergy Asthma Immunol Res. 2019 Jul;11(4):560-571. https://doi.org/10.4168/aair.2019.11.4.560