Thymidylate synthase as an oncogene?

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Thymidylate synthase as an oncogene? J.R Bertino, D Banerjee Cancer Cell Volume 5, Issue 4, Pages 301-302 (April 2004) DOI: 10.1016/S1535-6108(04)00086-8

Figure 1 The thymidylate cycle E2F-1 as the heterodimer E2F-1/DP-1 activates transcription of TS. The other two enzymes of the thymidylate cycle are dihydrofolate reductase (DHFR) and serine hydroxymethyltransferase (SHMT). FH2, dihydrofolate; FH4, tetrahydrofolate; CH2FH4, 5-10-methylene tetrahydrofolate. Cancer Cell 2004 5, 301-302DOI: (10.1016/S1535-6108(04)00086-8)