ATG16L1 Prevents Lethal T-Cell Alloreactivity Mediated By Dendritic Cells Yusuke Shono, MD, PhD, Vanessa Hubbard-Lucey, PhD, Katie Maurer, Anne Mary Dickinson,

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ATG16L1 Prevents Lethal T-Cell Alloreactivity Mediated By Dendritic Cells Yusuke Shono, MD, PhD, Vanessa Hubbard-Lucey, PhD, Katie Maurer, Anne Mary Dickinson, BSc, PhD, Ernst Holler, MD, PhD, Kenneth H. Cadwell, PhD, Marcel R.M. van den Brink, MD, PhD Biology of Blood and Marrow Transplantation Volume 20, Issue 2, Pages S23-S24 (February 2014) DOI: 10.1016/j.bbmt.2013.12.005 Copyright © 2014 Terms and Conditions

Figure ATG16C1HM recipients have increased mortality after allo-HSCT with increased expression of activation/maturation molecules in recipient DCs. (A, B) Lethally irradiated C57BL/6 wild-type or ATG16L1HM recipients were transplanted with B10.BR TCD BM cells with 2 × 106 B10.BR T cells. (A) Survival. (B) Histogram overlays of activation/maturation molecules expression of recipient DCs. Recipient spleens were harvested on day 7 after allo-HSCT. Data are representative of two independent experiments.∗∗∗, P < 0.001. Biology of Blood and Marrow Transplantation 2014 20, S23-S24DOI: (10.1016/j.bbmt.2013.12.005) Copyright © 2014 Terms and Conditions