Correlation between pancreatic 111In-exendin accumulation and BCM

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Chelsea McCarty, Professor Salt Lake Community College Fall 2010.

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Correlation between pancreatic 111In-exendin accumulation and BCM Correlation between pancreatic 111In-exendin accumulation and BCM. A: The uptake of 111In-exendin in the pancreas (n = 45), expressed as the percentage of the injected dose per gram of tissue (%ID/g) (y-axis, determined by ex vivo counting of the entire pancreas), showed a strong correlation with the BCM (expressed as percentage of the total pancreas [x-axis]), determined by morphometric analysis (Pearson r = 0.89, P < 0.0001). Correlation between pancreatic 111In-exendin accumulation and BCM. A: The uptake of 111In-exendin in the pancreas (n = 45), expressed as the percentage of the injected dose per gram of tissue (%ID/g) (y-axis, determined by ex vivo counting of the entire pancreas), showed a strong correlation with the BCM (expressed as percentage of the total pancreas [x-axis]), determined by morphometric analysis (Pearson r = 0.89, P < 0.0001). B: The rats treated with insulin are represented as open squares and non–insulin-treated rats with open circles. C: The level of glycemia was plotted for every individual rat. The animals were categorized based on their nonfasting blood glucose levels at the time point of imaging as follows: nondiabetic (<11.1 mmol/L) (open circles), mild hyperglycemia (11.1 to <22.2 mmol/L) (open squares), and moderate hyperglycemia (22.2–33.3 mmol/L) (open triangles). Maarten Brom et al. Diabetes 2018;67:2012-2018 ©2018 by American Diabetes Association