GREY MATTER CONNECTIVITY IS ASSOCIATED WITH CLINICAL PROGRESSION IN NON-DEMENTED, AMYLOID POSITIVE PATIENTS Betty M. Tijms, Mara ten Kate, Sander C.J.

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GREY MATTER CONNECTIVITY IS ASSOCIATED WITH CLINICAL PROGRESSION IN NON-DEMENTED, AMYLOID POSITIVE PATIENTS Betty M. Tijms, Mara ten Kate, Sander C.J. Verfaillie, Alida A. Gouw, Charlotte E. Teunissen, Frederik Barkhof, Philip Scheltens, Wiesje M. van der Flier Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 12, Issue 7, Pages P9-P10 (July 2016) DOI: 10.1016/j.jalz.2016.06.072 Copyright © 2016 Terms and Conditions

Figure 1 Linear trend analysis of normalized clustering coefficient (gamma) and the small world parameter. Both these network parameters had highest values in patients with subjective cognitive decline who remained stable over time, and the lowest in MCI patients who progressed to dementia. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P9-P10DOI: (10.1016/j.jalz.2016.06.072) Copyright © 2016 Terms and Conditions

Figure 2 Survival curves for the time to dementia onset in subjects with subjective cognitive impairment or mild cognitive impairment due to Alzheimer's disease with separate lines for clustering coefficient tertiles: blue represents subjects with the most lowest values, green represents intermediate values and red line represents subjects with the highest values. Alzheimer's & Dementia: The Journal of the Alzheimer's Association 2016 12, P9-P10DOI: (10.1016/j.jalz.2016.06.072) Copyright © 2016 Terms and Conditions