RORα deficiency in Tregs results in exaggerated skin inflammation in response to EC sensitization. RORα deficiency in Tregs results in exaggerated skin.

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RORα deficiency in Tregs results in exaggerated skin inflammation in response to EC sensitization. RORα deficiency in Tregs results in exaggerated skin inflammation in response to EC sensitization. (A) Schematic of the experimental mouse model. (B to H) Representative H&E-stained sections (B); quantification of epidermal thickness (C); number of CD45+ cells (D), CD11b+Siglec-F+ eosinophils (E), mast cells, neutrophils, and basophils (left), and CD4+FOXP3− Teffs, CD4+FOXP3+ Tregs, and ILCs (right) (F); relative Il4 (right) and Il13 (left) mRNA expression (G); and numbers of IL-5+ CD4+ T cells and ILCs (H) in saline and OVA-sensitized skin of Foxp3eyfp-creRorafl/fl mice (also designated as cKO) and Foxp3eyfp-cre controls (also designated as WT). n = 3 to 7 mice per group. Columns and bars represent means and SEM. *P < 0.05, ***P < 0.001. Nidhi Malhotra et al. Sci. Immunol. 2018;3:eaao6923 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works