Double-positive CD4 and CD8 Sézary syndrome

Slides:

Advertisements

Similar presentations

Volume 2, Issue 6, Pages (November 2016)

Advertisements

Jeff Donovan, MD, PhD, FRCPC JAAD Case Reports

Volume 3, Issue 2, Pages (March 2017)

Volume 1, Issue 4, Pages (July 2015)

Flood syndrome JAAD Case Reports

Expression of PD-L1 in mastocytosis

Hemorrhagic lesion on the chest wall after trauma

Exploring the relationship between natural killer cells and cutaneous squamous cell carcinoma development Muneeb Ilyas, BSc, Collin M. Costello, BS,

Cynthia M. Magro, MD, Tracy L. Davis, MD, PhD, Drew J.B. Kurtzman, MD

Can the level of CD52 expression on Sézary cells be used to predict the response of Sézary syndrome to alemtuzumab? Iolanda Conde Fernandes, MD, Marta.

Volume 3, Issue 6, Pages (November 2017)

Volume 1, Issue 4, Pages (July 2015)

Double-positive CD4 and CD8 Sézary syndrome

An enlarging, ulcerated scalp nodule

Conjunctivitis, mucosal erosions, and moist cutaneous plaques

Digital metastasis of tongue squamous cell carcinoma

Volume 2, Issue 3, Pages (May 2016)

Volume 2, Issue 4, Pages (July 2016)

Volume 3, Issue 1, Pages (January 2017)

Development of bullous pemphigoid during nivolumab therapy

Exuberant scale crust of the scalp

Volume 3, Issue 4, Pages (July 2017)

Substance P in keratosis follicularis spinulosa decalvans

Flesh-colored papules and nodules on the face

Treatment of psoriasis vulgaris using low-dose naltrexone

Romidepsin-induced neutrophilic urticaria

Is the hip prosthesis responsible for this rash?

CD4+CD25+FOXP3+ malignant T cells in Sézary syndrome are not necessarily functional regulatory T cells David A. Wada, MD, Mark R. Pittelkow, MD, Nneka.

Mark D. Heibel, MD, Haley D. Heibel, MS JAAD Case Reports

Two cases of maggot debridement therapy in pyoderma gangrenosum

Successful treatment of livedoid vasculopathy with rivaroxaban

An unusual case of cytotoxic peripheral T-cell lymphoma

Carvedilol for the treatment of red scrotum syndrome

Ken Shiraishi, MD, PhD, Koji Sayama, MD, PhD JAAD Case Reports

Infliximab therapy for Netherton syndrome: A case report

Severe contiguous perianal Crohn's disease

Anjali Shroff, MD, Emma Guttman-Yassky, MD, PhD JAAD Case Reports

Nicole Maillet-Lebel, MD, Marie-Marthe Thibeault, MD, FRCPC

Volume 2, Issue 6, Pages (November 2016)

Diffuse pruritic papules

Squamous cell carcinomas of the skin responsive to erlotinib: 5 cases

Volume 4, Issue 6, Pages (July 2018)

An atypical presentation of a rare disease

Hemorrhagic bullae of the oral mucosa

A possible association between mycosis fungoides and Muir-Torre syndrome: Two disorders with microsatellite instability Daniel J. Lewis, BA, Madeleine.

Grace A. Hile, BS, Lori Lowe, MD, J. Michelle Kahlenberg, MD, PhD

Epidermotropic poorly differentiated adenocarcinoma of colon presenting as a diffuse erythematous petechial rash Luis-Antonio Sardiña, MD, Addie Walker,

Refractory Sweet's syndrome successfully treated with rituximab

Slowly progressive chest rash in an elderly woman

Balanitis associated with FOLFIRI chemotherapy

Circinate oral and genital mucositis

Volume 3, Issue 6, Pages (November 2017)

Linear alopecia areata

Papules developing in an old tattoo

Volume 1, Issue 6, Pages (November 2015)

Olga Vornicova, MD, Gil Bar-Sela, MD JAAD Case Reports

Persistent injection site nodules from exenatide: Successful treatment with intralesional triamcinolone Kayla Riswold, BS, Valerie Flynn, MD JAAD Case.

Bilateral sole hyperkeratosis and nonhealing foot mass

Painful violaceus bullae of the hands

Identification of novel targetable mutations in metastatic anorectal melanoma by next- generation sequencing Emily D. Cai, BA, Jinah Kim, MD, PhD JAAD.

Widespread hyperpigmented rash present for 1 year

Extensive skin necrosis

Multisystemic Langerhans cell histiocytosis in an adult

Erythema multiforme in a child with Kawasaki disease

Lip ulceration in an immunocompromised patient

Figurate erythema for 20 years

Bryan Baillis, MD, John C. Maize, MD JAAD Case Reports

Tattoo pigment removal by halo nevus phenomenon

Grace A. Hile, BS, Lori Lowe, MD, J. Michelle Kahlenberg, MD, PhD

Whitish elbow nodules in a healthy 11-year-old girl

Presentation transcript:

Double-positive CD4 and CD8 Sézary syndrome Denis Miyashiro, MD, Marina Passos Torrealba, MSc, Kelly Cristina Manfrere, MSc, Juliana Pereira, MD, PhD, Maria Notomi Sato, PhD, José Antonio Sanches, MD, PhD JAAD Case Reports Volume 3, Issue 6, Pages 485-488 (November 2017) DOI: 10.1016/j.jdcr.2017.06.036 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Diffuse erythema and scaling. JAAD Case Reports 2017 3, 485-488DOI: (10.1016/j.jdcr.2017.06.036) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Immunohistochemistry showing exocytosis of small lymphocytes positive for CD4. (Original magnification: ×100.) JAAD Case Reports 2017 3, 485-488DOI: (10.1016/j.jdcr.2017.06.036) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Immunohistochemistry showing exocytosis of small lymphocytes positive for CD8. (Original magnification: ×100.) JAAD Case Reports 2017 3, 485-488DOI: (10.1016/j.jdcr.2017.06.036) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 A, Immunophenotyping of lymphocytes. Sixty-eight percent of CD4+ and CD8+ malignant cells. B, CD107a and interferon gamma production after stimulation with phorbol miristate acetate in TCD4+CD8+ neoplastic cells, TCD4+CD8–, and TCD4–CD8+ cells. Peripheral blood mononuclear cells were cultured with phorbol miristate acetate (50 ng/mL) and ionomycin (1 μg/mL) for 20 hours. T cells were assessed for interferon production and activation markers expression by flow cytometry. JAAD Case Reports 2017 3, 485-488DOI: (10.1016/j.jdcr.2017.06.036) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions