Accumulation of β-amyloid deposits assessed by immunohistochemistry in E3FAD and E4FAD mice across dietary treatments. Accumulation of β-amyloid deposits.

Slides:

Advertisements

Similar presentations

FMRP suppresses dendritic Arc protein levels.

Advertisements

Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” by Karthikeyan Veeraraghavalu, Can Zhang, Sean.

Biphasic Alteration of the Inhibitory Synapse Scaffold Protein Gephyrin in Early and Late Stages of an Alzheimer Disease Model Eva Kiss, Karin Gorgas,

Fig. 2. Increased Aβ plaque load in 16-month-old APP/PS1;C3 KO mice.

Effects of propofol and surgery on neuropathology and cognition in the 3xTgAD Alzheimer transgenic mouse model F. Mardini, J.X. Tang, J.C. Li, M.J. Arroliga,

Aβ amyloid cortical and hippocampal pathology in McGill Thy1-APP transgenic (Tg) mice. A1: Absence of Aβ in non-transgenic (Non-Tg) littermate (ccx = cortex;

DH E2 infusion significantly increased phosphorylation of the p42 isoform of ERK (A) and of Akt (B) in the DH of OVX females, but not sham GDX males. DH.

ApoE4 Accelerates Early Seeding of Amyloid Pathology

Type 1 immunity drives metabolic disease but protects against NAFLD

Volume 78, Issue 4, Pages (May 2013)

Incidence and spatial extent of epileptiform events observed in widefield calcium imaging. Incidence and spatial extent of epileptiform events observed.

Age‐related amyloid deposition in APPPS1‐21 mice.

Molecular and morphological analysis of Pitrm1+/− mouse brain

Volume 43, Issue 1, Pages (July 2004)

Active avoidance is impaired in aged mice in both multimodal and visual versions of the task. Active avoidance is impaired in aged mice in both multimodal.

Peptidergic nociceptor markers are reduced in DRG from Nav-Tsc2 mice.

qRT-PCR validation of differential expression.

Effects of E2 on levels of phospho-CREB in the DH of OVX females, sham males, and GDX males. Effects of E2 on levels of phospho-CREB in the DH of OVX females,

HDAC4N increases with Braak stage in CA2 hippocampal pyramidal cells.

Neuronal ATM level is reduced in mouse models of AD

Amyloid pathology in APP/PSEN1 and APP/PSEN1/APOEnull mice.

Learned helplessness assessed by active avoidance in dMHbCKO mice.

Stress does not affect the volume fraction of fine astrocytic protrusions across the BA and the dCA3 area of the hippocampus. Stress does not affect the.

MET/β-catenin complexes during synapse development.

Repolarization of membrane potential is associated with a decreased membrane conductance. Repolarization of membrane potential is associated with a decreased.

Loss of Cav1 function does not disrupt formation of dual projecting CPN/FPN axonal projections at P8. Loss of Cav1 function does not disrupt formation.

PTX-induced reporter protein expression in the brain of the IEG reporter line. PTX-induced reporter protein expression in the brain of the IEG reporter.

The complexity as well as the total dendritic length of ApoE-deficient adult-born granule cells are significantly reduced. The complexity as well as the.

Fig. 2. Deficiency of neuronal HS leads to reduced neuroinflammation.

APT1 palmitoylation and localization.

Effect of FGF8 on R-C marker expression.

Western blot analysis of α-Syn-BAC-Tg/GBA-hetero-KO mice at multiple time points. Western blot analysis of α-Syn-BAC-Tg/GBA-hetero-KO mice at multiple.

RA signaling in early postnatal PFC

c-Fos in RFMes GABAergic neurons across groups.

Synaptic density is significantly impaired in male FBN-ARO-KO mice.

Synapse composition is unaltered in SynDIG1-deficient synapses.

Adult scent marking and open-field activity in the presence of female urine. Adult scent marking and open-field activity in the presence of female urine.

Metabolic outcomes associated with DIO in E3FAD and E4FAD mice.

Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. Gene deletion of PGC-1α leads to the loss of dopamine neurons in the SNpc. A,

MSK1 is necessary for BDNF-dependent CREB phosphorylation in area CA1.

PTZ-induced c-Fos and Arc proteins in hippocampal dentate gyrus

Dissection and clearing of brain subregions.

PTZ-induced neuronal activity visualized by IEGs

Tissue distribution of MMP-9 and MMP-2 in adult rat brain.

A, Cells present in clonal clusters were classified based on morphology (see Materials and Methods) into type 1 progenitor cells (A.1); type 2/3 progenitor.

Behavioral task and performance.

NestinCre-mediated deletion of CTCF results in activation of caspase-mediated apoptosis. NestinCre-mediated deletion of CTCF results in activation of caspase-mediated.

CRISPRa induction of Bdnf mRNA increases spike and burst frequency in hippocampal neurons cultured on microelectrode arrays (MEAs). CRISPRa induction of.

GABAARs in RFMes GABAergic neurons across groups.

AP-induced axonal swelling and subsequent migration of microglial processes to the periaxonal area. AP-induced axonal swelling and subsequent migration.

TOMA does not affect NFTs in posterior hypothalamus or cortex.

Elimination of dendritic spines per 2 d.

ErbB4 expression in PV+ and PV– interneurons and the ErbB4 expression levels in hippocampus of WT and the NRG1tg-type-I mice. ErbB4 expression in PV+ and.

High titers of peripheral anti-Aβ antibodies do not reduce Aβ deposits in aged Tg-SwDI mice. High titers of peripheral anti-Aβ antibodies do not reduce.

Smad1 induces target genes in conditioned DRG neurons.

Global levels of AcH4 are increased in DRG neurons after peripheral axotomy. Global levels of AcH4 are increased in DRG neurons after peripheral axotomy.

Brain ischemic tolerance model using mouse MCAO

Astrocyte number and morphologic status assessed by GFAP immunohistochemistry in E3FAD and E4FAD mice across dietary treatments. Astrocyte number and morphologic.

PNU enhances Ca2+ flux mediated by an engineered variant of the human α7 nAChR. PNU enhances Ca2+ flux mediated by an engineered variant.

Depletion of Gr-1+ neutrophils by systemic anti-Gr-1 treatment prevents exacerbated neurodegeneration in RAG1-KO mice. Depletion of Gr-1+ neutrophils by.

CA1 neuronal loss and recovery following forebrain ischemia.

Dendritic morphology of hippocampal CA1 neurons from wild-type and cbdnf ko animals. Dendritic morphology of hippocampal CA1 neurons from wild-type and.

Passive immunization with CT α-syn antibodies improved TH pathology and neuroinflammation in the striatum of α-syn tg mice. Passive immunization with CT.

Expression of Rapgef2 and Rapgef6 in the E13.5 and E15.5 brains.

Sensorimotor cortex recordings have a canonical shape.

A, B, 5-HT1A immunoreactivity in hippocampal dendrites (CA3) of saline-treated (A) and fluoxetine-treated (B) rats. A, B, 5-HT1A immunoreactivity in hippocampal.

BDNF protein is expressed in neurons and astrocytes of hippocampus after pilocarpine-induced SE. A, Representative confocal images of hippocampal subfields.

Fig. 2. SUS reduces Aβ plaques in an AD mouse model.

Densin knock-out mice have normal gross neuroanatomy and low body weight. Densin knock-out mice have normal gross neuroanatomy and low body weight. A,

Activation and expression of the transgene.

Presentation transcript:

Accumulation of β-amyloid deposits assessed by immunohistochemistry in E3FAD and E4FAD mice across dietary treatments. Accumulation of β-amyloid deposits assessed by immunohistochemistry in E3FAD and E4FAD mice across dietary treatments. A, Representative images of β-amyloid immunoreactivity in entorhinal cortex and hippocampus in E3FAD and E4FAD males maintained on control and Western diets. Scale bar, 100 µm. β-Amyloid burden was quantified as immunoreactivity load in E3FAD and E4FAD mice in control and Western diets groups in (B) entorhinal cortex, and hippocampal subregions (C) subiculum, (D) CA1, and (E) CA2/3. Data are presented as mean (±SEM) values; n = 7–11/group. E3FAD mice are shown as circles, E4FAD mice are shown as squares; control diet groups are indicated as open symbols, and Western diet groups as filled symbols. *, p < 0.05 relative to genotype-matched mice in control diet condition. #, p < 0.05 relative to E3FAD mice in same diet condition. V. Alexandra Moser, and Christian J. Pike eNeuro 2017;4:ENEURO.0077-17.2017 ©2017 by Society for Neuroscience