Melanotic macule of nail unit and its clinicopathologic spectrum

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Presentation transcript:

Melanotic macule of nail unit and its clinicopathologic spectrum Sameera Husain, MD, Richard K. Scher, MD, David N. Silvers, MD, A. Bernard Ackerman, MD Journal of the American Academy of Dermatology Volume 54, Issue 4, Pages 664-667 (April 2006) DOI: 10.1016/j.jaad.2005.11.1098 Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Broad pigmented streak from right third finger of 68-year-old woman is expression of melanotic macule of nail matrix. B, Melanin is apparent in matrix epithelium. Sections are stained by periodic acid–Schiff, which heightens recognition of melanin. (Original magnification ×40.) Journal of the American Academy of Dermatology 2006 54, 664-667DOI: (10.1016/j.jaad.2005.11.1098) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 A, Very dark pigmented streak from right hallux of 55-year-old woman is manifestation of melanotic macule of nail matrix. B, Abundant melanin is present in matrix epithelium. (Periodic acid–Schiff stain; original magnification ×40.) Journal of the American Academy of Dermatology 2006 54, 664-667DOI: (10.1016/j.jaad.2005.11.1098) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 A, Thin pigmented streak from right thumb of 74-year-old man represents melanotic macule. B, Melanin can be seen in matricial epithelium but is less obvious than it would be were sections stained by periodic acid–Schiff. (Hematoxylin-eosin stain; original magnification ×40.) Journal of the American Academy of Dermatology 2006 54, 664-667DOI: (10.1016/j.jaad.2005.11.1098) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 A, Narrow pigmented streak of left thumb of 51-year-old woman is expression of melanoma in situ. B, Melanoma in situ is characterized by melanocytes disposed as solitary units and in tiny nests throughout matrix epithelium. (Hematoxylin-eosin stain; original magnification ×25.) Journal of the American Academy of Dermatology 2006 54, 664-667DOI: (10.1016/j.jaad.2005.11.1098) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 5 A, Darkly pigmented melanotic streak of left thumb of 32-year-old man is manifestation of junctional nevus. B, In contrast to histopathologic findings of melanoma in situ (Fig 4, B), this junctional nevus is characterized by discrete nests of melanocytes in lower part of matrical epithelium, particularly dermoepidermal junction. (Hematoxylin-eosin stain; original magnification ×16.) Journal of the American Academy of Dermatology 2006 54, 664-667DOI: (10.1016/j.jaad.2005.11.1098) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions