Fig. 5 In vivo evaluation of F-insulin for treatment of type 1 diabetic minipig. In vivo evaluation of F-insulin for treatment of type 1 diabetic minipig.

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Fig. 5 In vivo evaluation of F-insulin for treatment of type 1 diabetic minipig. In vivo evaluation of F-insulin for treatment of type 1 diabetic minipig. (A) BGLs of type 1 diabetic minipigs treated with native insulin or F-insulin. The insulin dose was set to 1 U/kg. The BGLs were measured continuously by CGMS. Each curve represents the BGL change obtained from a single minipig. The same color indicated the data from the same pig. Three pigs (designated as 1, 2, or 3) were used in this study. The black arrow indicated the injection of insulin or F-insulin. The orange arrows indicated the two meals for pigs. (B) Oral glucose tolerance test toward diabetic minipigs at 4 hours after treatment of F-insulin (0.5 U/kg). Glucose was given at 0.5 g/kg. (C) Intravenous glucose tolerance test in diabetic minipigs at 4 hours after treatment of F-insulin at a dose of 1 U/kg. Dextrose solution (5%) was intravenously infused at a dose of 0.75 g/kg. The rate of infusion was set to 1 liter/hour. Figures from left to right indicated pigs 1, 2, and 3, respectively. Jinqiang Wang et al. Sci Adv 2019;5:eaaw4357 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).