Fig. 5. Col IV–Ac2-26 NPs decrease lesion area, necrotic area, and oxidative stress in brachiocephalic arterial plaques. Col IV–Ac2-26 NPs decrease lesion.

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Assessment of Unstable Atherosclerosis in Mice

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Fig. 5. Col IV–Ac2-26 NPs decrease lesion area, necrotic area, and oxidative stress in brachiocephalic arterial plaques. Col IV–Ac2-26 NPs decrease lesion area, necrotic area, and oxidative stress in brachiocephalic arterial plaques. Ldlr−/− mice were fed the Western diet for 12 weeks and then injected intravenously with Col IV NPs containing scrambled peptide (Scrm) or Ac2-26 once per week for 5 weeks, with the mice remaining on the diet. (A and B) Representative whole-mount (A) or cross-sectioned specimens (B) of BCA lesions were visualized en bloc or in cross section. Scale bar, 100 μm. (C to F) Cross sections were quantified for lesion area (C), necrotic area (D), ICAM immunostaining (E), and superoxide (DHE fluorescence) (F). Data are for individual mice, with means shown as horizontal lines (n = 8 to 10 separate mice, two sections per mouse). *P < 0.05, **P < 0.01, ***P < 0.001, Student’s t test. Gabrielle Fredman et al., Sci Transl Med 2015;7:275ra20 Copyright © 2015, American Association for the Advancement of Science