MMP expression at the growth plate.

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MMP expression at the growth plate. MMP expression at the growth plate. Dark-field photographs of tissue sections of metatarsals from 1-week-old WT (A,C) and MMP-9−/− mice (B,D) hybridized with antisense probes against MMP-13 (A,B) and MMP-14 (C,D). MMP-13 is expressed in cells at the cartilage-bone junction, consistent with the previously reported expression in terminal hypertrophic chondrocytes (A,B, arrowheads) and in the metaphysis (A,B, asterisks), in both WT and MMP-9−/− mice. In addition, MMP-13 is also expressed in some lower hypertrophic chondrocytes in MMP-9−/− mice (B, arrows). MMP-14 is expressed in cells at the cartilage-bone junction (C,D, arrowheads) and the metaphysis (C,D, asterisks). It is also expressed in the perichondrium (C,D, arrows). Bars, 200 μm. Nathalie Ortega et al. Dis. Model. Mech. 2010;3:224-235 ©2010 by The Company of Biologists Limited