Volume 139, Issue 1, Pages (July 2010)

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Volume 139, Issue 1, Pages 249-258 (July 2010) Serotonin Signaling Is Altered in Irritable Bowel Syndrome With Diarrhea but Not in Functional Dyspepsia in Pediatric Age Patients Christophe Faure, Natalie Patey, Cindy Gauthier, Elice M. Brooks, Gary M. Mawe Gastroenterology Volume 139, Issue 1, Pages 249-258 (July 2010) DOI: 10.1053/j.gastro.2010.03.032 Copyright © 2010 AGA Institute Terms and Conditions

Figure 1 (A) Enteroendocrine (chromogranin-positive) cell and (B) enterochromaffin (5-HT–positive) cell counts in the gastric mucosa of patients with FD are similar as compared with control subjects and subjects with organic diseases. (C) Enteroendocrine (chromogranin-positive) cell and (D) enterochromaffin (5-HT–positive) cell counts in the rectal mucosa of patients with IBS, control subjects, and subjects with organic diseases with inflammation grading greater than 2 (inflamed organic disorders) and without inflammation (noninflamed organic disorders). No significant differences were detected in enteroendocrine and enterochromaffin cell counts of samples from patients with IBS as compared with controls. Biopsies with inflammation grading greater than 2 obtained from subjects with organic disease showed significant lower enteroendocrine and enterochromaffin cell counts as compared with controls and biopsies without inflammation (grade, <1). Gastroenterology 2010 139, 249-258DOI: (10.1053/j.gastro.2010.03.032) Copyright © 2010 AGA Institute Terms and Conditions

Figure 2 (A) 5-HT content in the gastric mucosa of patients with FD is similar as compared with control subjects and subjects with organic diseases. (B) 5-HT content in the rectal mucosa of patients with IBS, control subjects, and subjects with organic diseases with inflammation grading greater than 2 (inflamed organic disorders) and without inflammation (noninflamed organic disorders). 5-HT content is significantly higher in the rectal mucosa of patients with IBS as compared with control subjects. 5-HT levels are significantly lower in biopsies obtained from subjects with inflamed organic disorders as compared with controls and biopsies from noninflamed organic disorders. Gastroenterology 2010 139, 249-258DOI: (10.1053/j.gastro.2010.03.032) Copyright © 2010 AGA Institute Terms and Conditions

Figure 3 Relative expression of TpH-1 mRNA in the rectal mucosa of patients with IBS, control subjects, and subjects with organic diseases with inflammation grading greater than 2 (inflamed organic disorders) and without inflammation (noninflamed organic disorders). No significant differences were detected in TpH-1 transcript levels of samples from patients with IBS as compared with controls. TpH-1 transcript levels are significantly higher in biopsies obtained from subjects with inflamed organic disorders as compared with controls and biopsies from noninflamed organic disorders. Gastroenterology 2010 139, 249-258DOI: (10.1053/j.gastro.2010.03.032) Copyright © 2010 AGA Institute Terms and Conditions

Figure 4 Relative expression of SERT mRNA in the rectal mucosa of patients with IBS, control subjects, and subjects with organic diseases with inflammation grading greater than 2 (inflamed organic disorders) and without inflammation (noninflamed organic disorders). A significantly lower level of SERT transcript was detected in samples from patients with IBS as compared with controls. SERT transcript levels are significantly increased in biopsies obtained from subjects with inflamed organic disorders as compared with controls and biopsies from noninflamed organic disorders. Gastroenterology 2010 139, 249-258DOI: (10.1053/j.gastro.2010.03.032) Copyright © 2010 AGA Institute Terms and Conditions