Energy stores in quadriceps muscles at rest (white bars) and after treadmill exercise (black bars) in WT and HSL KO mice. Energy stores in quadriceps muscles.

Slides:

Advertisements

Similar presentations

A B Figure S1. Macroscopic analyses of the ColIITgcog mouse phenotype (female mice) (A) Graph and table of body weights and percentage differences of female.

Advertisements

Morphology of white adipose tissue and muscle in S1/3 KO mice of different ages Morphology of white adipose tissue and muscle in S1/3 KO mice of different.

B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition. B-cell precursors in the spleen of Eμ-Myc mice are reduced by mTORC1 inhibition.

TFE3 regulates glucose homeostasis

Metabolic profile of Tfe3 KO mice

Prmt7 deficiency causes a fiber-type switch toward glycolytic.

Impaired glucose tolerance in adult S1/3 KO mice on a normal chow

GM-CSF–producing γδT cells are involved in the development of EAM

Postnatal depletion of Drosha in the endothelium in mice results in HHT-like vascular abnormalities. Postnatal depletion of Drosha in the endothelium in.

Fig. 3. Differential mPFC PV neuron activity during exploratory behaviors in CNTNAP2 KO and WT mice. Differential mPFC PV neuron activity during exploratory.

mGPDH is not essential to muscle development

Plant growth in experimental paddies.

Complementation of sos1 mutant.

Deletion of Srf with a skeletal muscle-specific Cre transgene.

Supplementary Figure 5: Effect of S48168 on normalized organ and skeletal muscle weights after 12 weeks of treatment for all the experimental groups from.

IL-27 contributes to IR expression by lung T cells during toxoplasmosis. IL-27 contributes to IR expression by lung T cells during toxoplasmosis. (A) Il27p28-GFP.

Alterations in Notch signaling affect the frequency of intermediate and main IHBD branches. Alterations in Notch signaling affect the frequency of intermediate.

Fig. 2. Body weight and size analysis of A1/A2-KO mice

Hyperinsulinemic-euglycemic clamps revealed that obese TPL2KO mice have an improved insulin sensitivity compared with obese WT mice. Hyperinsulinemic-euglycemic.

Fig. 6. STK35 KO mice show ovary defects.

WASH cKO mice display a normal pancreatic development.

TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin resistance. TG-CRP mice display fasting hyperglycemia, hyperinsulinemia, and insulin.

PD-1, but not PD-L1, expressed by the BDC2

MTORC1 regulates basal GLUT4 protein expression independent of VWR exercise. mTORC1 regulates basal GLUT4 protein expression independent of VWR exercise.

Serum adiponectin is significantly lower in obese gestational diabetes mellitus (GDM) women compared with obese women at 26 weeks of gestation. Serum adiponectin.

FGF21 signaling in hypothalamus is blocked by FGFR1 neutralizing antibody. FGF21 signaling in hypothalamus is blocked by FGFR1 neutralizing antibody. Twelve-week-old.

Skeletal muscle characteristics of HFD-induced obese mice.

Smad3-KO adipose tissues have increased FA uptake and β-oxidation.

Measurement of insulin release from islets evoked by glucose, diazoxide, and high K+. Measurement of insulin release from islets evoked by glucose, diazoxide,

Glucose tolerance in WT and TRPM2-KO mice.

Fasting-induced lipolysis is impaired in weight-matched Ugcgf/f//CamKCreERT2 mice 3–4 weeks pi. Fasting-induced lipolysis is impaired in weight-matched.

Glycogen synthase and glycogen phosphorylase activities after in vivo AICAR treatment. Glycogen synthase and glycogen phosphorylase activities after in.

Lower SNS activity in WAT of fasted Ugcgf/f//CamKCreERT2 mice.

BAFF-deficient (BAFFnull) and anti-BAFF antibody (Ab)–treated obese mice exhibit superior glucose metabolic control compared with WT and Bnull mice. BAFF-deficient.

Insulin sensitivity in athletes and sedentary normal-weight and obese, young, and old individuals. Insulin sensitivity in athletes and sedentary normal-weight.

The effect of VSG on body weight and body fat in GLP-1r KO mice.

A: Chemical structure of pterosin A

Phenotypic characterization of splenic and islet-infiltrating B-cells in 12-week-old NOD female mice. Phenotypic characterization of splenic and islet-infiltrating.

Chop deletion preserves β-cell function in P58IPK−/− mice.

AgRP-ATF4 KO mice have decreased food intake and enhanced energy expenditure. AgRP-ATF4 KO mice have decreased food intake and enhanced energy expenditure.

Metabolic parameters of Id1−/− and wild-type mice fed a standard chow diet (hatched bars and striped bars, respectively) or a high-fat diet (black bars.

Subchronic glycemic effects after vehicle, metformin, SGLT2I, or combination treatment. Subchronic glycemic effects after vehicle, metformin, SGLT2I, or.

Atrasentan reduces albuminuria in diabetic apoE KO mice.

SENP2 overexpression increases FAO by upregulating expression of FAO-associated enzymes in muscle. SENP2 overexpression increases FAO by upregulating expression.

MϕRIP140KD mice show browning in vWAT.

Saccharification yields.

Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.

Hepatic fuel metabolism in male 5αR1-KO and WT mice

Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance. Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance.

Insulin resistance and hepatic steatosis in ASKO mice.

Treatment of ob/ob mice with TTR-ASOs improves insulin sensitivity.

PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded skin. PEDF inhibits Wnt/T-cell factor/β-catenin signaling in resting and wounded.

Effects of Rosi treatment on ASKO mice.

Effects of chow-diet feeding on control and TRIB3 MOE mice.

AKT thr308 phosphorylation related to total AKT2 protein in SOL muscle (m. soleus) (A) and EDL muscle (m. extensor digitorum longus) (D) and AKT ser472.

Urinary albumin excretion and histology of glomeruli.

Metabolic effects of VSG in GLP-1r KO mice.

Glucose-stimulated insulin secretion, plasma glucagon levels, and pancreatic hormone contents. Glucose-stimulated insulin secretion, plasma glucagon levels,

SKO mice display hypertrophic cardiomyopathy with systolic and diastolic dysfunction. SKO mice display hypertrophic cardiomyopathy with systolic and diastolic.

GTTs and ITTs. A: GTTs of WT (◇), LepTg (♦), Akita (open circles), and LepTg:Akita (closed circles) mice at 8 and 16 weeks of age. GTTs and ITTs. A: GTTs.

Loss of Phb2 in β-cells induces development of diabetes over a 3-week period in β-Phb2−/− mice. Loss of Phb2 in β-cells induces development of diabetes.

Lack of OcaB impairs age-associated B-lymphocyte accumulation in WAT

β-Cell–specific deletion of Phb2 renders mice diabetic.

Pioglitazone lowers glucose overload but only partially improves cardiac function. Pioglitazone lowers glucose overload but only partially improves cardiac.

M-MDSC:mast cell cross-talk in the regulation of TNFα production.

Elimination of dendritic spines per 2 d.

mTORC1 is required for malignant transformation in the Eμ-Myc model.

A, effect of IP6 feeding on the weight of LUT organs normalized to body weight. A, effect of IP6 feeding on the weight of LUT organs normalized to body.

Effects of PCSK7 rs genotype and CHO diets on changes and reversion in fasting insulin levels and HOMA-IR during the 2-year intervention in white.

Densin knock-out mice have normal gross neuroanatomy and low body weight. Densin knock-out mice have normal gross neuroanatomy and low body weight. A,

Presentation transcript:

Energy stores in quadriceps muscles at rest (white bars) and after treadmill exercise (black bars) in WT and HSL KO mice. Energy stores in quadriceps muscles at rest (white bars) and after treadmill exercise (black bars) in WT and HSL KO mice. Content of total muscle DAG (A), muscle sn-1,3 DAG and sn-1,2 DAG muscle (B), sn-1,3 DAG (C), muscle sn-1,2 DAG (D), IMTG (E), and muscle glycogen (F). Measured between age 16 and 25 weeks (n = 7–9 in each group). dw, dry weight. Data are expressed as the mean ± SEM. ##Effect of exercise (P < 0.01); †significant effect of genotype (P < 0.05); ††a significant effect of genotype (P < 0.01); ¶¶significant effect of sn-1,2 DAG (P < 0.01). Annette Karen Serup et al. Diabetes 2016;65:2932-2942 ©2016 by American Diabetes Association