Metabolic effects of VSG in GLP-1r KO mice.

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Metabolic effects of VSG in GLP-1r KO mice. Metabolic effects of VSG in GLP-1r KO mice. GLP-1r WT and KO mice that received VSG or sham surgery underwent a mixed-meal tolerance test on postoperative day 18 (n = 8 WT sham; n = 11 WT VSG; n = 12 KO sham; and n = 16 KO VSG). Blood glucose (A) was measured after gavage of a standard liquid diet, and plasma insulin was determined at baseline (B) and 15 min (C). Food intake (D) was significantly lower in VSG-operated mice of both genotypes from days 0–3, but by days 28–31 there was no effect of surgery and KO mice consumed less than WT controls. Food choice was assessed by macronutrient selection (n = 6 WT sham; n = 7 WT VSG; n = 9 KO sham; and n = 12 KO VSG), showing that VSG mice of both genotypes decrease fat intake and increase carbohydrate intake (E). Data are represented as mean ± SEM. **P < 0.01; ***P < 0.001. Hilary E. Wilson-Pérez et al. Diabetes 2013;62:2380-2385 ©2013 by American Diabetes Association