Synaptic density is significantly impaired in male FBN-ARO-KO mice.

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Synaptic density is significantly impaired in male FBN-ARO-KO mice. Synaptic density is significantly impaired in male FBN-ARO-KO mice. A, IHC analysis for the expression and localization of both the presynaptic marker synaptophysin and the postsynaptic marker PSD95 in the male hippocampal CA1 region. B–D, Quantitative analysis for the relative intensity of synaptophysin (SYN) (B), PSD-95 (C), and SYN/PSD-95 contacts which represents synaptic density (D) compared with FLOX mice. E–H, IHC (E) and further quantitative analysis of synaptophysin (F), PSD95 (G), and SYN/PSD-95 contact (H) intensity in male cerebral cortex. I, Western blot confirmation for synaptophysin and PSD95 expression in hippocampus and cortex from both male and ovx female mice. J, K, Quantitative analysis of Western blot analysis for both hippocampus (J) and cortex (K). Data are shown as means ± SEM. n = 5. *p < 0.05 versus FLOX group. SYN, Synap, Synaptophysin. Yujiao Lu et al. J. Neurosci. 2019;39:2792-2809 ©2019 by Society for Neuroscience