Western blot analysis shows inhibition of fluorocitrate on glial hyperactivation and functions. Western blot analysis shows inhibition of fluorocitrate.

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by Xiao Z. Shen, You Li, Liang Li, Kandarp H. Shah, Kenneth E

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Western blot analysis shows inhibition of fluorocitrate on glial hyperactivation and functions. Western blot analysis shows inhibition of fluorocitrate on glial hyperactivation and functions. A, B, Microinjection of fluorocitrate (FC+; 100 pmol) significantly inhibits enhanced expression of GFAP (A) and S100β (B) at 14 d after CCI-ION (p < 0.05; n = 3 per group) but does not affect their expression at 14 d after sham operation, compared with vehicle treatment (−). C, D, Fluorocitrate (100 pmol) significantly reverses upregulation of TNF-α (C) and IL-1β (D) at 14 d after CCI-ION (p < 0.05; n = 3 per group) but does not change their expression at 14 d after sham operation, compared with vehicle treatment (−). E, There are no effects of FC (100 pmol) on increases in CD11b expression at 3 d after sham operation and CCI-ION, compared with vehicle (Veh) (n = 3 per group). However, the microglial inhibitor MC (1 pmol) attenuates or abolishes CD11b increase in the RVM at 3 d after sham or CCI treatment. All asterisks indicate p < 0.05 when compared with the naive (n = 3 per group) in A–E. Error bars indicate SEM. Feng Wei et al. J. Neurosci. 2008;28:10482-10495 ©2008 by Society for Neuroscience