Volume 55, Issue 3, Pages (March 1999)

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Volume 55, Issue 3, Pages 907-916 (March 1999) Effect of diabetes and aminoguanidine therapy on renal advanced glycation end-product binding Sherif Youssef, Dominique T. Nguyen, Tina Soulis, Sianna Panagiotopoulos, George Jerums, Mark E. Cooper Kidney International Volume 55, Issue 3, Pages 907-916 (March 1999) DOI: 10.1046/j.1523-1755.1999.055003907.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Gross localization of 125I-AGE-BSA in vitro binding in the rat kidney. (A) Total binding for control. (B) Control + aminoguanidine. (C) Diabetic. (D) Diabetic + aminoguanidine. (E) Nonspecific binding. Kidney International 1999 55, 907-916DOI: (10.1046/j.1523-1755.1999.055003907.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Binding isotherms generated by in vitro incubation of tissue sections with 125I-AGE-BSA with increasing concentrations of unlabeled AGE-BSA (◊), unlabeled AGE-RNase (○), native BSA (□), and native Rnase (▪). The y-axis represents binding density as quantitated by the MCID program. Kidney International 1999 55, 907-916DOI: (10.1046/j.1523-1755.1999.055003907.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 In vitro125I-AGE-BSA binding in the renal cortex (A) and medulla (B). Data are shown as mean ± SEM. Abbreviations are: Con, control; diab, diabetic; AG, aminoguanidine. *P < 0.01 vs. control, †P < 0.01 vs. diabetic. Kidney International 1999 55, 907-916DOI: (10.1046/j.1523-1755.1999.055003907.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 4 In vitro emulsion autoradiography that shows binding to renal tubules (t) but not to glomeruli (g). (A) Bright field (magnification ×200). (B) Dark field (magnification ×200). Kidney International 1999 55, 907-916DOI: (10.1046/j.1523-1755.1999.055003907.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 5 In vivo emulsion autoradiography that shows binding to proximal tubules (p) but not to glomeruli (g) or distal tubules (d). (A) Bright field (magnification ×200). (B) Dark field (magnification ×200). (C) Bright field with lectin counterstain (magnification ×400). Kidney International 1999 55, 907-916DOI: (10.1046/j.1523-1755.1999.055003907.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 6 AGE levels in renal cortical homogenates as measured by fluorescence (A) and radioimmunoassay (B). Abbreviations are: Con, control; diab, diabetic; AG, aminoguanidine. *P < 0.01 vs. control, †P < 0.01 vs. diabetic. Kidney International 1999 55, 907-916DOI: (10.1046/j.1523-1755.1999.055003907.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Kidney International 1999 55, 907-916DOI: (10. 1046/j. 1523-1755. 1999 Kidney International 1999 55, 907-916DOI: (10.1046/j.1523-1755.1999.055003907.x) Copyright © 1999 International Society of Nephrology Terms and Conditions