Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling Bérénice Herszberg, DMV, David Ramos-Barbón, MD, PhD, Meiyo Tamaoka, MD,

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Presentation transcript:

Heaves, an asthma-like equine disease, involves airway smooth muscle remodeling Bérénice Herszberg, DMV, David Ramos-Barbón, MD, PhD, Meiyo Tamaoka, MD, James G. Martin, MD, Jean-Pierre Lavoie, DMV Journal of Allergy and Clinical Immunology Volume 118, Issue 2, Pages 382-388 (August 2006) DOI: 10.1016/j.jaci.2006.03.044 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 ASM growth in heaves. A, Small bronchus of a horse with heaves. B, Size-matched bronchus in a control horse. C, ASM mass, heaves vs control groups. Scale bars: 250 μm. ∗P < .05. Journal of Allergy and Clinical Immunology 2006 118, 382-388DOI: (10.1016/j.jaci.2006.03.044) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Immunostaining for PCNA (nuclear dark signal) colocalized with α-SMA (cytoplasmic red signal). A, High-magnification detail. B, Equivalent microscopic field in a size-matched airway of a control horse. C, PCNA+ cell numbers/mm2. Scale bars: 50 μm. ∗P < .05. Journal of Allergy and Clinical Immunology 2006 118, 382-388DOI: (10.1016/j.jaci.2006.03.044) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Apoptosis detected by TUNEL and colocalized with α-SMA. The plot represents TUNEL+ cells/mm2 in heaves vs controls. ∗P < .05. Journal of Allergy and Clinical Immunology 2006 118, 382-388DOI: (10.1016/j.jaci.2006.03.044) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Regression analysis of the ASM mass (A), and the numbers of PCNA+ (B) and TUNEL+ (C) ASM cells versus basement membrane length. Control horses: circles and flat (thin) linear regression functions. Heaves: triangles and thick regression curves. In heaves, the increments in ASM mass (A) and proliferating cells (B) are larger the smaller the airways. Journal of Allergy and Clinical Immunology 2006 118, 382-388DOI: (10.1016/j.jaci.2006.03.044) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 5 Regression analysis of (A) ASM mass and (B) apoptotic cells versus proliferating ASM cells/mm2. ∗Outlier. C, Summary graph of the increases in proliferating (7-fold) and apoptotic (6-fold) myocytes and ASM mass (close to 3-fold). ∗P < .05 vs control. Journal of Allergy and Clinical Immunology 2006 118, 382-388DOI: (10.1016/j.jaci.2006.03.044) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions