Schematic of [U-13C]glucose in the brain.

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Schematic of [U-13C]glucose in the brain. Schematic of [U-13C]glucose in the brain. Simplified schematic of 13C-labeling patterns after the metabolism of [U-13C]glucose via glycolysis and the TCA cycle. Empty circles, 12C; black filled circle, 13C; gray filled circles, 13C derived from 13C-labeled oxaloacetate that enters the second turn of the TCA cycle (gray dotted lines). *Metabolites that were not measured in this study. GA3P, glyceraldehyde 3-phosphate; 13BPG, 1,3-bisphosphoglycerate; 3PG, 3-phosphoglycerate; 2PG, 2-phosphoglycerate; Ac-CoA, acetyl CoA; OAA, oxaloacetate. Tanya S. McDonald et al. eNeuro 2017;4:ENEURO.0341-16.2017 ©2017 by Society for Neuroscience