Serious Pulmonary Toxicity Secondary to Novel Hepatitis C Antiviral Therapy in a Liver Transplant Recipient  Richard A. Helmers, MD, Thomas J. Byrne, MD, Lewis J. Wesselius, MD, Kevin O. Leslie, MD  Mayo Clinic Proceedings  Volume 90, Issue 9, Pages 1294-1297 (September 2015) DOI: 10.1016/j.mayocp.2015.06.015 Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Diffuse ground-glass opacities on computed tomography of the chest. Mayo Clinic Proceedings 2015 90, 1294-1297DOI: (10.1016/j.mayocp.2015.06.015) Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Simeprevir-sofosbuvir–related diffuse alveolar damage. A, Diffuse alveolar damage is evident in the surgical lung biopsy specimen, with hyaline membranes (hm) readily visible. The process was not uniform, with spared areas visible (hematoxylin-eosin, original magnification ×100). B, At higher magnification, intensely vacuolated type 2 cells and macrophages (v) are present with scattered intra-alveolar eosinophils (arrow). These combined features are highly suggestive of medication toxicity (hematoxylin-eosin, original magnification ×400). Mayo Clinic Proceedings 2015 90, 1294-1297DOI: (10.1016/j.mayocp.2015.06.015) Copyright © 2015 Mayo Foundation for Medical Education and Research Terms and Conditions