Biology of endothelin receptors in the collecting duct

Slides:

Advertisements

Similar presentations

Date of download: 9/18/2016 From: The Cardiomyopathy of Overload: An Unnatural Growth Response in the Hypertrophied Heart Ann Intern Med. 1994;121(5):

Advertisements

Volume 66, Issue 5, Pages (November 2004)

Volume 66, Issue 5, Pages (November 2004)

Cellular Signaling Ch. 11.

Endothelium-derived mediators: the vasodilators prostacyclin (PGI2) and nitric oxide (NO) and the vasoconstrictor endothelin (ET-1). Endothelium-derived.

Volume 4, Issue 3, Pages (June 2006)

Intracellular Regulation of Ion Channels in Cell Membranes

Volume 84, Issue 3, Pages (September 2013)

How do we critically use long-acting muscarinic receptor antagonists and beta- adrenergic receptor agonists monotherapy, or these combination therapies.

Eric Niederhoffer SIU-SOM

HFpEF, a Disease of the Vasculature: A Closer Look at the Other Half

Figure 1 The role of GPCRs in the regulation of human physiology

Axel Pflueger, MD, Timothy S. Larson, MD, Karl A

Volume 78, Issue 2, Pages (July 2010)

The key pathways and classes of drugs that have been approved for the treatment of pulmonary arterial hypertension. The key pathways and classes of drugs.

Volume 71, Issue 11, Pages (June 2007)

Vascular endothelial dysfunction in cirrhosis

Role of Endothelin in the Pathogenesis of Hypertension

Mechanisms of rIPC. Mechanisms of rIPC. AP-1, activator protein-1; cGMP, cyclic guanosine monophosphate; CGRP, calcitonin gene-related peptide; COX2, cyclooxygenase.

Cellular mechanisms of acute versus delayed preconditioning

Volume 61, Issue 3, Pages (March 2002)

Renal and extrarenal regulation of potassium

Adrenergic and Cholinergic Control in the Biology of Epidermis: Physiological and Clinical Significance Sergei A. Grando, Mark R. Pittelkow, Karin U.

ANO1: an additional key player in cyst growth

Mark S Taylor, A.Marie McMahon, Jason D Gardner, Joseph N Benoit

The sources of oxidative stress in the vessel wall

Volume 77, Issue 1, Pages 5-6 (January 2010)

Volume 64, Issue 4, Pages (October 2003)

Let's look at cysts from both sides now

Volume 81, Issue 12, Pages (June 2012)

Anaesthesia and myocardial ischaemia/reperfusion injury

Volume 82, Issue 11, Pages (December 2012)

Thomas Quaschning, Jan Galle, Christoph Wanner

Juan-Carlos García-Pagán, Jorge Gracia-Sancho, Jaume Bosch

Nirupama Ramkumar, Donald E. Kohan Kidney International

Cyclooxygenase-2 in the kidney: good, BAD, or both?

Vasopressin regulation of renal sodium excretion

Volume 86, Issue 2, Pages (August 2014)

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Volume 74, Issue 8, Pages (October 2008)

Calcium sensing in podocytes

Thomas Mueller, Benjamin Dieplinger Kidney International

Scorpions, snakes, and Fontan failure: The dawn of a new ERA?

Jasper Pannemans, Jan Tack Gastroenterology

Edward J. Weinman, Deborah Steplock, Shirish Shenolikar

Nephrology Crossword: Glomerulonephritis

Insulin resistance and hypertension: new insights

Volume 60, Issue 2, Pages (August 2001)

A man with a hole in his penis

Specific signal transduction mechanisms

Volume 71, Issue 11, Pages (June 2007)

G proteins and hypertension: An alternative candidate gene approach

Volume 72, Issue 3, Pages (August 2007)

Toshinori Aoyagi, Taka-aki Koshimizu, Akito Tanoue

Hypoxic pulmonary vasoconstriction in cardiothoracic surgery: basic mechanisms to potential therapies Ben M Tsai, MD, Meijing Wang, MD, Mark W Turrentine,

Mechanism of action for pulmonary arterial hypertension medications.

AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla

Regulation of renal function by prostaglandin E receptors

Volume 76, Issue 9, Pages (November 2009)

Aldosterone and potassium secretion by the cortical collecting duct

Tumor necrosis factor-α in cisplatin nephrotoxicity: A homebred foe?

Microsomal prostaglandin E synthase-1 and blood pressure regulation

Volume 75, Issue 8, Pages (April 2009)

Molecular biology of distal nephron sodium transport mechanisms

Jurgen Schnermann, Josephine P. Briggs Kidney International

Proteinuria and hypertension with tyrosine kinase inhibitors

Volume 66, Issue 5, Pages (November 2004)

Volume 56, Issue 4, Pages (October 1999)

Targeting cyclooxygenase-2 in human neoplasia

Presentation transcript:

Biology of endothelin receptors in the collecting duct Donald E. Kohan Kidney International Volume 76, Issue 5, Pages 481-486 (September 2009) DOI: 10.1038/ki.2009.203 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Schematic of ET receptor B (ETRB) regulation of the collecting duct Na transport. COX, cyclooxygenase; ENaC, epithelial Na channel; MAPK, mitogen-activated protein kinase; NO, nitric oxide; NOS, nitric oxide synthase; PGE2, prostaglandin E2; PLA, phospholipase A; Src, src tyrosine kinase. Kidney International 2009 76, 481-486DOI: (10.1038/ki.2009.203) Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 2 Schematic of ET receptor B regulation of the collecting duct water transport. AC3/6, adenylyl cyclase 3 and 6 isoforms; AQP2, aquaporin-2; AQP2-P, phosphorylated AQP2; cAMP, cyclic adenosine monophosphate; DAG, diacylglycerol; PKA, protein kinase A; PKC, protein kinase C; PLC, phospholipase C; V2, vasopressin receptor. Kidney International 2009 76, 481-486DOI: (10.1038/ki.2009.203) Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 3 Schematic of ET receptor B regulation of the collecting duct proton and bicarbonate transport. cGMP, cyclic guanosine monophosphate; GC, guanylyl cyclase; NO, nitric oxide; NOS, nitric oxide synthase; PKG, cGMP-dependent protein kinase. Kidney International 2009 76, 481-486DOI: (10.1038/ki.2009.203) Copyright © 2009 International Society of Nephrology Terms and Conditions