Efficacy of immunomodulation in the treatment of profound thrombocytopenia after adult cardiac surgery J. Scott Rankin, MD, Charles W. Stratton, MD

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Efficacy of immunomodulation in the treatment of profound thrombocytopenia after adult cardiac surgery J. Scott Rankin, MD, Charles W. Stratton, MD The Journal of Thoracic and Cardiovascular Surgery Volume 147, Issue 2, Pages 808-815 (February 2014) DOI: 10.1016/j.jtcvs.2013.09.051 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Mean ± standard deviation of platelet counts for 3 days before (−3) to 5 days after (+5) beginning IVIG therapy in 20 postoperative patients experiencing pT. IVIG therapy was begun on day zero. Time course of the therapeutic response was assessed using a linear regression and spline function, with a statistical knot at day 0, coincident with starting IVIG. IVIG was associated with a consistent reversal of developing pT and a highly significant treatment effect, using each patient as his or her own control (P < .001). See text for details. IVIG, Intravenous immunoglobulin. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 808-815DOI: (10.1016/j.jtcvs.2013.09.051) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions