An Association Between Sebaceous Carcinoma and Microsatellite Instability in Immunosuppressed Organ Transplant Recipients Catherine A. Harwood, Victoria.

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An Association Between Sebaceous Carcinoma and Microsatellite Instability in Immunosuppressed Organ Transplant Recipients Catherine A. Harwood, Victoria J. Swale, Veronique A. Bataille, Anthony G. Quinn, Lucy Ghali, Sejal V. Patel, Isis Dove-Edwin, Rino Cerio, Jane M. McGregor Journal of Investigative Dermatology Volume 116, Issue 2, Pages 246-253 (February 2001) DOI: 10.1046/j.1523-1747.2001.01233.x Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Sebaceous carcinoma from patient DD. Hematoxylin and eosin stain, scale bar: 25 μm. The tumor is comprised of proliferating, invasive islands of cells showing pleomorphism, mitoses, and sebaceous differentiation, manifest as finely vacuolated or foamy cytoplasm, with more differentiation at the center of the nests. Journal of Investigative Dermatology 2001 116, 246-253DOI: (10.1046/j.1523-1747.2001.01233.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 MSI in paired normal and tumor DNA. Microsatellite analyses of DNA from paired control (C) and microdissected sebaceous carcinoma tumor (T) at locus D1S201. Examples from three individuals are shown: (a) patient BM; (b) patient JG; (c) patient DD. Tumors demonstrating MSI are denoted T*; → indicates two alleles of control DNA; ← denotes additional bands due to MSI. Journal of Investigative Dermatology 2001 116, 246-253DOI: (10.1046/j.1523-1747.2001.01233.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Immunohistochemical analysis of hMLH1 and hMSH2 expression in SGC. (a) hMLH1; (b) hMSH2. Strong nuclear staining with hMLH1 is seen in the overlying normal epidermis of this sebaceous carcinoma from RTR, JG (indicated by ←). Nuclear staining is also seen throughout the tumor (T). Strong nuclear staining in the overlying epidermis (←) is also seen with hMLH2; however, there is almost complete loss of nuclear hMSH2 staining in the tumor (T). Scale bar: 50 μm. Journal of Investigative Dermatology 2001 116, 246-253DOI: (10.1046/j.1523-1747.2001.01233.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions