Association between CD14 polymorphisms and serum soluble CD14 levels: Effect of atopy and endotoxin inhalation Tricia D. LeVan, PhD, Olivier Michel,

Slides:

Advertisements

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Advertisements

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Control of immunopathology during chikungunya virus infection Caroline Petitdemange, PhD, Nadia Wauquier, PhD, Vincent Vieillard, PhD Journal of Allergy.

D-dimer: A biomarker for antihistamine-resistant chronic urticaria

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

The loss of IgM memory B cells correlates with clinical disease in common variable immunodeficiency Rita Carsetti, MD, Maria Manuela Rosado, PhD, Simona.

Anne M. Fitzpatrick, PhD, MSCR, W. Gerald Teague, MD

Fatty acids, inflammation, and asthma

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment Lennart M. Roesner, PhD, Petra Kienlin, Gabriele.

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom Yize I. Wan, BMedSci, David P. Strachan,

Is 9 more than 2 also in allergic airway inflammation?

Desensitization to Chemotherapeutic Agents

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD

Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels Kim de Jong, PhD, Judith M. Vonk, PhD, Wim Timens, PhD, Yohan.

Fatty acids, inflammation, and asthma

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

Vitamin D levels and food and environmental allergies in the United States: Results from the National Health and Nutrition Examination Survey

Physician needs in health informatics: Just ask the docs

Peter M. Wolfgram, MD, David B. Allen, MD

Functional variants of 17q12-21 are associated with allergic asthma but not allergic rhinitis Anand Kumar Andiappan, PhD, Yang Yie Sio, BSc, Bernett.

The future of allergy/immunology: Promising young investigators

An age-dependent association of mannose-binding lectin-2 genetic variants on HIV-1– related disease in children Kumud K. Singh, PhD, Alexis Lieser, MD,

Maternal microchimerism protects against the development of asthma

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Reply Journal of Allergy and Clinical Immunology

Ordinary vibratory angioedema is not generally associated with ADGRE2 mutation Zuotao Zhao, MD, PhD, Sascha Reimann, MD, Shan Wang, MD, Yuhan Wang, MD,

Polymorphisms of chitinases are not associated with asthma

Patterns and predictors of atopic dermatitis disease control past childhood: An observational cohort study Katrina Abuabara, MD, MA, Ole Hoffstad, MS,

Roles of arginase variants, atopy, and ozone in childhood asthma

Low diversity of the gut microbiota in infants with atopic eczema

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation Leif Bjermer, MD Journal of Allergy.

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Effect of day care attendance on sensitization and atopic wheezing differs by Toll-like receptor 2 genotype in 2 population-based birth cohort studies

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Claus Bachert, MD, PhD, Cezmi A. Akdis, MD

Effect of ingested H1 antihistamines on methacholine challenge

What is an “eosinophilic phenotype” of asthma?

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Opposite effects of CD14/-260 on serum IgE levels in children raised in different environments Waltraud Eder, MD, Walt Klimecki, PhD, Lizhi Yu, MD, Erika.

Advances in the approach to the patient with food allergy

Geographic variability in childhood asthma prevalence in Chicago

Healthy subjects express differences in clinical responses to inhaled lipopolysaccharide that are related with inflammation and with atopy Olivier Michel,

Matthew J. Loza, PhD, Susan Foster, PhD, Stephen P

The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects Neil E. Alexis, PhD, Haibo Zhou, PhD,

News Beyond Our Pages Journal of Allergy and Clinical Immunology

Machine learning, natural language programming, and electronic health records: The next step in the artificial intelligence journey? Neil Mehta, MBBS,

Genome-wide association study reveals class I MHC–restricted T cell–associated molecule gene (CRTAM) variants interact with vitamin D levels to affect.

Alvaro A. Cruz, MD, Robert M

Measles and immunomodulation

Genetic variants in the GATA3 gene are not associated with asthma and atopic diseases in German children Kathrin Suttner, MSc, Martin Depner, MSc, Norman.

Neil E. Alexis, PhD, John C. Lay, PhD, Martha Almond, RRT, David B

Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy Stacie M. Jones, MD, A.

Päivi M. Salo, PhD, Samuel J. Arbes, DDS, MPH, PhD, Patrick W

Macrolide antibiotics and asthma treatment

Frederikke K. Lomholt, BMSc, Sune F. Nielsen, PhD, Børge G

CD14 polymorphisms and serum CD14 levels through childhood: A role for gene methylation? Monica Cheng Munthe-Kaas, MD, PhD, Tale Mæhre Torjussen, MD,

Socioeconomic status and inflammatory processes in childhood asthma: The role of psychological stress Edith Chen, PhD, Margaret D. Hanson, MA, Laurel.

Asthma: The past, future, environment, and costs

Dendritic cells in nasal mucosa of subjects with different allergic sensitizations Susanne M. Reinartz, MD, Joost van Tongeren, MD, Danielle van Egmond,

Environmental factors and eosinophilic esophagitis

Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults Somnath Mukhopadhyay, FRCPCH, MD, PhD, Joseph Sypek, PhD,

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,

The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy Jennifer M. Maloney, MD, Magnus Rudengren, BSc, Staffan.

Natural history of cow’s milk allergy

Primary prevention of asthma and allergy

Presentation transcript:

Association between CD14 polymorphisms and serum soluble CD14 levels: Effect of atopy and endotoxin inhalation Tricia D. LeVan, PhD, Olivier Michel, MD, Mieke Dentener, PhD, Jörgen Thorn, MD, PhD, Francoise Vertongen, PhD, Lena Beijer, PhD, Fernando D. Martinez, MD Journal of Allergy and Clinical Immunology Volume 121, Issue 2, Pages 434-440.e1 (February 2008) DOI: 10.1016/j.jaci.2007.08.050 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Pairwise r2 values between the CD14 polymorphisms −1619, −1359, and −159. Values of r2 were calculated by using the software Linkage Disequilibrium Analyzer 1.0 and are shown in shaded boxes. The LD statistic r2 describes the similarity of patterns between pairs of polymorphic sites. Journal of Allergy and Clinical Immunology 2008 121, 434-440.e1DOI: (10.1016/j.jaci.2007.08.050) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Association of CD14 haplotypes with systemic inflammatory markers before and after endotoxin inhalation. The graphs represent results for LBP (top), CRP (middle), and WBCs (bottom). Mean log LBP level ± SEM (in milligrams per liter), mean log CRP level ± SEM (in milligrams per liter), and mean WBC level ± SEM (in cells per liter) are on the y-axis, and time after endotoxin inhalation is on the x-axis. CD14 haplotypes are defined by loci −1619/−1359/−159. P values were calculated by using ANOVA at each time point. n, Number of chromosomes. Journal of Allergy and Clinical Immunology 2008 121, 434-440.e1DOI: (10.1016/j.jaci.2007.08.050) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Association of CD14 polymorphisms with serum sCD14 levels before and after endotoxin inhalation. The graphs represent results for CD14/−1619 (top left), CD14/−1359 (top right), CD14/−159 (bottom left), and CD14/haplotypes (bottom right). Serum sCD14 levels are shown as mean log sCD14 ± SEM in nanograms per milliliter on the y-axis, and time after endotoxin inhalation is shown on the x-axis. CD14 haplotypes are defined by loci −1619/−1359/−159. P values for CD14/−1619, CD14/−159, and CD14/haplotypes were calculated by using ANOVA for data at time 0 and time 24 hours. P values for CD14/−1359 were calculated by using the t test for GG versus GT/TT. Genotype results: n, number of subjects; haplotype results: n, number of chromosomes. Journal of Allergy and Clinical Immunology 2008 121, 434-440.e1DOI: (10.1016/j.jaci.2007.08.050) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Association between CD14 polymorphisms and positive SPT responses Association between CD14 polymorphisms and positive SPT responses. Criteria for positive SPT response are described in the Methods section. CD14 haplotypes are defined by loci −1619/−1359/−159. P values for −1619, −159, and haplotypes were derived by using ANOVA. P values for −1359 were calculated by using t tests for GG versus GT/TT. Genotype results: n, number of subjects; haplotype results: n, number of chromosomes. Journal of Allergy and Clinical Immunology 2008 121, 434-440.e1DOI: (10.1016/j.jaci.2007.08.050) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions