Volume 11, Issue 1, Pages 87-97 (January 2004) Biosynthesis of the Angiogenesis Inhibitor Borrelidin by Streptomyces parvulus Tü4055  Carlos Olano, Barrie Wilkinson, César Sánchez, Steven J Moss, Rose Sheridan, Vidya Math, Alison J Weston, Alfredo F Braña, Christine J Martin, Markiyan Oliynyk, Carmen Méndez, Peter F Leadlay, José A Salas  Chemistry & Biology  Volume 11, Issue 1, Pages 87-97 (January 2004) DOI: 10.1016/j.chembiol.2003.12.018

Figure 1 Structure of Borrelidin Chemistry & Biology 2004 11, 87-97DOI: (10.1016/j.chembiol.2003.12.018)

Figure 2 Schematic Representation of the Borrelidin Gene Cluster B, BamHI. ORFs involved in borrelidin biosynthesis are colored in black and those not involved in gray or white, the gray ones corresponding to homologous genes in S. coelicolor showing the same genetic organization. Chemistry & Biology 2004 11, 87-97DOI: (10.1016/j.chembiol.2003.12.018)

Figure 3 Scheme Representing the Repeated DNA Sequences within the Borrelidin PKS Genes Chemistry & Biology 2004 11, 87-97DOI: (10.1016/j.chembiol.2003.12.018)

Figure 4 Module Organization in the Borrelidin PKS and Proposed Model for Borrelidin Biosynthesis ACP, acyl carrier protein; AT, acyltransferase; ATa, malonyl-specific acyltransferase; ATp, methylmalonyl-specific acyltransferase; ER, enoyl reductase; KR, β-keto reductase; DH, dehydratase; KS, β-ketoacyl-acylcarrier protein synthase; TE, thioesterase. Chemistry & Biology 2004 11, 87-97DOI: (10.1016/j.chembiol.2003.12.018)

Figure 5 Putative Biosynthetic Pathway for Trans-1,2-CPDA from 4HPA Chemistry & Biology 2004 11, 87-97DOI: (10.1016/j.chembiol.2003.12.018)