Establishment and comparison of two reliable hyperkinetic pulmonary hypertension models in rabbits Chuanzhen Liu, MD, Zhibo Yan, MD, PhD, Changcun Fang,

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Presentation transcript:

Establishment and comparison of two reliable hyperkinetic pulmonary hypertension models in rabbits Chuanzhen Liu, MD, Zhibo Yan, MD, PhD, Changcun Fang, MD, PhD, Guangqing Cao, MD, PhD, Biao Wang, MD, PhD, Sijie Li, MD, Shuming Wu, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 148, Issue 5, Pages 2353-2359 (November 2014) DOI: 10.1016/j.jtcvs.2013.12.066 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 End-to-side anastomosis (C) between the right common carotid artery (A) and right internal jugular vein (B). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2353-2359DOI: (10.1016/j.jtcvs.2013.12.066) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Drawing of surgical techniques and differences between (A) common carotid artery and jugular vein shunt by cuff style method (CJSC) and (B) common carotid artery and jugular vein shunt by anastomosis (CJSA). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2353-2359DOI: (10.1016/j.jtcvs.2013.12.066) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Right common carotid artery (A) and right internal jugular vein (B) shunt in cuff style (C). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2353-2359DOI: (10.1016/j.jtcvs.2013.12.066) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Systolic pulmonary arterial pressure (SPAP) before and after closure of shunt vessels in (A) the common carotid artery and jugular vein shunt by cuff style method (CJSC) group and (B) the common carotid artery and jugular vein shunt by anastomosis (CJSA) group. In the CJSC group, the SPAP before closure was greater than that after closure in 1 month, with no significant difference after 2 months (*P < .05). In the CJSA group, the SPAP before closure was greater than that after closure at 1 and 2 months, with no significant difference after 3 months (*P < .05). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2353-2359DOI: (10.1016/j.jtcvs.2013.12.066) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 5 The systolic pulmonary arterial pressure (SPAP), mean pulmonary arterial pressure (MPAP), and mean arterial pressure (MAP) after closure of shunt vessels. A and B, Compared with the sham operation group, the common carotid artery and jugular vein shunt by cuff style method (CJSC) group and common carotid artery and jugular vein shunt by anastomosis (CJSA) group showed greater SPAP and MPAP. Both SPAP and MPAP were increased at 6 months preoperatively and remained steady from 6 to 12 months (*P < .05). C, Compared with the sham operation group, no significant difference was found in the MAP between the CJSC and CJSA groups. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2353-2359DOI: (10.1016/j.jtcvs.2013.12.066) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 6 Right ventricular hypertrophy. Compared with the sham operation group, the common carotid artery and jugular vein shunt by cuff style method (CJSC) group and common carotid artery and jugular vein shunt by anastomosis (CJSA) group showed a greater ratio of the right ventricular mass to the left ventricular plus septum mass (RV/LV+S) (*P < .05). The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2353-2359DOI: (10.1016/j.jtcvs.2013.12.066) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 7 Pathologic changes in pulmonary artery postoperatively (hematoxylin-eosin stain, ×200). A, Sham operation group; B, grade I to II intimal thickening and medial hypertrophy of arterioles; C, grade III advanced medial thickening and severe narrowing or occlusions of arterioles; and D, grade IV-VI plexiform lesions of arterioles. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 2353-2359DOI: (10.1016/j.jtcvs.2013.12.066) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions