Inhibition of γ-secretase increased hair cell differentiation by upregulating Math1. a, Expression of Math1 in inner ear stem cells was increased after.

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Inhibition of γ-secretase increased hair cell differentiation by upregulating Math1. a, Expression of Math1 in inner ear stem cells was increased after treatment with a γ-secretase inhibitor and could be blocked by siRNA to Math1 but not by a nontargeting s... Inhibition of γ-secretase increased hair cell differentiation by upregulating Math1. a, Expression of Math1 in inner ear stem cells was increased after treatment with a γ-secretase inhibitor and could be blocked by siRNA to Math1 but not by a nontargeting siRNA based on qRT-PCR. b, Differentiation of hair cells (myosin VIIa, green) induced by the γ-secretase inhibitor was unaffected by nontargeting siRNA but was inhibited by siRNA directed at Math1. Labeled siRNA (red, arrowheads) was added to follow transfection. Blue, DAPI. Scale bar, 15 μm. c, The percentage of hair cells obtained after treatment with the γ-secretase inhibitor was significantly decreased by Math1 RNAi. The percentage was reduced to the level of the untreated control but was not decreased by nontargeting RNAi. Error bars, SE; *p < 0.05, **p < 0.01. Sang-Jun Jeon et al. J. Neurosci. 2011;31:8351-8358 ©2011 by Society for Neuroscience