Fig. 7 CAV dose target attainment in childhood TB.

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Fig. 7 CAV dose target attainment in childhood TB. CAV dose target attainment in childhood TB. Each data point is shown as the proportion of 10,000 children. (A) Pharmacokinetic parameters and concentrations of ceftazidime and avibactam in 10,000 simulated children treated with a CAV dose of 50/12.5 mg/kg are compared to those observed in the clinic in children treated with this same dose for other indications. Our simulated children achieved concentrations that are the same as those that were observed in the clinic by others (used here to benchmark), meaning that the simulations faithfully recapitulated concentrations that are achieved in children by the different doses. (B) The dose of 100 mg/kg achieved good target attainment for %TMIC of 47% up to an MIC of 64 mg/liter. (C) For the %TMIC of 63% target, only the dose of 200 mg/kg achieved good target attainment up to an MIC of 64 mg/liter. (D) A summary of the proportion of 10,000 children with TB who achieved each of the two target %TMIC values of 47 and 63% over the entire MIC range for each dose. The dose of 100 mg/kg achieves the target that gives the same kill rates as standard first-line drugs in 90% of the children and even higher kill rates in at least 60% of the children. This means that the dose of 100 mg/kg is recommended for clinical testing in children with TB. Devyani Deshpande et al. Sci Adv 2017;3:e1701102 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).