Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation and fear conditioning. Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation.

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Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation and fear conditioning. Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation and fear conditioning. Vehicle or U0126 (1 μg per mouse) were injected intrahippocampally 15 min before the training as described in Figure 3A. A, Intrahippocampal injection of U0126 prevented freezing behavior of the stress/FC group without affecting freezing of the FC group. B, Mice of the stress/FC group injected intrahippocampally with U0126 exhibited significantly lower pErk-1/2 levels than vehicle-injected animals. U0126 did not affect pErk-1/2 levels in mice of the FC group. C, Representative immunoblots. Statistically significant differences: *p < 0.01 versus stress/FC-vehicle group. Farahnaz Sananbenesi et al. J. Neurosci. 2003;23:11436-11443 ©2003 by Society for Neuroscience