Generation of platelet-derived microparticles in patients undergoing cardiac surgery is not affected by complement activation Jeanette M van den Goor,

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Presentation transcript:

Generation of platelet-derived microparticles in patients undergoing cardiac surgery is not affected by complement activation Jeanette M van den Goor, MSc, CP, Albert van den Brink, MD, Rienk Nieuwland, PhD, Willem van Oeveren, PhD, Peter M Rutten, CP, Robert Tepaske, MD, Jan G Tijssen, PhD, Augueste Sturk, PhD, Bas A de Mol, MD, PhD, León Eijsman, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 126, Issue 4, Pages 1101-1106 (October 2003) DOI: 10.1016/S0022-5223(03)01031-6

Figure 1 Systemic concentrations of PMPs and platelet counts in patients undergoing CPB. Concentrations of PMPs and platelet counts before bypass and after induction of anesthesia (baseline value; pre), 15 minutes after the start of bypass (15′CPB), at the end of bypass and after release of the aortic crossclamp (end CPB), and 30 minutes after administration of protamine sulfate (30′prot) are shown. The measurements were made in 25 patients treated with an uncoated oxygenator (ie, without Surface Modification, UMS group, open bars), 25 patients treated with an oxygenator coated with a BioPassive Surface (BPS group, shaded bars), and 21 patients treated with an oxygenator coated with a BioActive Surface (BAS group, striped bars). PMP concentrations (A) and platelet counts (B) were determined as described in the “Methods” section. No significant differences were present among the 3 oxygenator groups. Medians and interquartile ranges are presented. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1101-1106DOI: (10.1016/S0022-5223(03)01031-6)

Figure 2 Concentrations of systemic TCCs in patients undergoing CPB. TCC concentrations before bypass and after induction of anesthesia (baseline value, pre), 15 minutes after the start of bypass (15′CPB), at the end of bypass and after release of the aortic crossclamp (end CPB), and 30 minutes after administration of protamine sulfate (30′prot) are shown. The measurements were made in 25 patients treated with an uncoated oxygenator (ie, without Surface Modification (UMS group, open bars), 25 patients treated with an oxygenator coated with a BioPassive Surface (BPS group, shaded bars), and 21 patients treated with an oxygenator coated with a BioActive Surface (BAS group, striped bars) and performed as described in the “Methods” section. Medians and interquartile ranges are presented. The Journal of Thoracic and Cardiovascular Surgery 2003 126, 1101-1106DOI: (10.1016/S0022-5223(03)01031-6)