Fig. 5. Vitamin B12 supplementation in the host altered the transcriptome of P. acnes in the skin microbiota. Vitamin B12 supplementation in the host altered.

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Fig. 5. Vitamin B12 supplementation in the host altered the transcriptome of P. acnes in the skin microbiota. Vitamin B12 supplementation in the host altered the transcriptome of P. acnes in the skin microbiota. (A) The differentially expressed P. acnes OGUs between day 0 and day 14 samples from the healthy subjects supplemented with vitamin B12. The red and green colors represent the fold change of the OGUs. Red indicates up-regulation after vitamin B12 supplementation and green indicates down-regulation. The functional categories of the OGUs are labeled by the colored bars next to the OGU names. (B) The P. acnes gene expression profile of subject HL414 on day 14 after vitamin B12 supplementation (HL414_Day14) was similar to those from the acne patients and clustered together. The day 0 sample from subject HL414 (“HL414_Day0”, healthy skin, before vitamin B12 supplementation) was similar to the samples from other healthy subjects. Samples from the acne patients were labeled in red (“Acne”), and samples from the healthy subjects were labeled in green (“Healthy,” “Day0,” “Day14”), except for HL414_Day14. Dezhi Kang et al., Sci Transl Med 2015;7:293ra103 Copyright © 2015, American Association for the Advancement of Science