Clinical Nutrition Experimental

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Clinical Nutrition Experimental

Clinical Nutrition Experimental

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Clinical Nutrition Experimental Dipeptiven® improves kidney pathology in a rat model of chronic kidney disease Melanie K. Bothe, Dirk Berressem, Rosa Abele, Heinrich Topp, Birgit Alteheld, Peter Stehle, Johannes Harleman, Martin Westphal, John F. Stover Clinical Nutrition Experimental Volume 25, Pages 11-19 (June 2019) DOI: 10.1016/j.yclnex.2018.07.003 Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Three weeks after 5/6 nephrectomy the rats received a continuous intravenous infusion of either alanyl-glutamine (Dipeptiven®), alanine or saline. Ala-Gln = alanyl-glutamine. Clinical Nutrition Experimental 2019 25, 11-19DOI: (10.1016/j.yclnex.2018.07.003) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 Ala-Gln infusion of 3.0 g/kg/day, but not 0.5 g/kg/day, increased the plasma glutamine concentrations on infusion days 4 and 7. Data reported as mean and interquartile range (IQR). Clinical Nutrition Experimental 2019 25, 11-19DOI: (10.1016/j.yclnex.2018.07.003) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 Plasma urea (A) and plasma creatinine (C) levels are increased in the nephrectomized animals compared to sham controls (grey shaded horizontal bar), while ammonia levels (B) are not. Ala-Gln infusion did not increase creatinine and ammonia levels, but increased urea levels were observed compared to nephrectomized controls in the animals receiving 3.0 g/kg/day infusion. Statistical significance was reached for this observation on day 6. ** = p < 0.01, data reported as mean and IQR. Clinical Nutrition Experimental 2019 25, 11-19DOI: (10.1016/j.yclnex.2018.07.003) Copyright © 2018 The Authors Terms and Conditions

Fig. 4 (A) Representative picture of saline receiving nephrectomized animals showing chronic progressive nephropathy with global glomerular sclerosis (arrow heads) and tubular proteinaceous casts (asterisks). (B) Glomerular sclerosis and tubular proteinaceous casts were absent in animals receiving 3.0 g/kg/day alanyl-glutamine intravenously for 9 consecutive days. Clinical Nutrition Experimental 2019 25, 11-19DOI: (10.1016/j.yclnex.2018.07.003) Copyright © 2018 The Authors Terms and Conditions