Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms Veronica Jackson, MD, Therese Olsson, BMA, Sanela Kurtovic,

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Presentation transcript:

Matrix metalloproteinase 14 and 19 expression is associated with thoracic aortic aneurysms Veronica Jackson, MD, Therese Olsson, BMA, Sanela Kurtovic, PhD, Lasse Folkersen, MSc, Valentina Paloschi, MSc, Dick Wågsäter, PhD, Anders Franco-Cereceda, MD, PhD, Per Eriksson, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 144, Issue 2, Pages 459-466 (August 2012) DOI: 10.1016/j.jtcvs.2011.08.043 Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 PCA of Affymetrix Human Exon 1.0 ST Array meta probe set level data of 12 MMP and 4 TIMP genes expressed in aortic samples from 109 patients. Three-dimensional score plots showing PC 1 to PC 3 plane of nondilated (black) and dilated (red) aortic samples, BAV and TAV together (A), TAV (B), and BAV (C). A PCA, in this case, is a projection to 3 dimensions from 16 variables that are composed of the gene expression levels of the MMPs included in the study. Each patient will thereby be represented by a point in a 3-dimensional PC plane that summarizes the original 16 dimensional properties of the particular patient. PCA, Principal components analysis; PC, principal component; BAV, bicuspid aortic valve; TAV, tricuspid aortic valve; MMP, matrix metalloproteinase; TIMP, tissue inhibitors of metalloproteinase. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 459-466DOI: (10.1016/j.jtcvs.2011.08.043) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 PCA of Affymetrix Human Exon 1.0 ST Array meta probe set level data of 12 MMP and 4 TIMP genes expressed in aortic samples from 40 patients with TAV. A, PC score plot showing nondilated (black) and dilated (red) aortic samples. B, Loading PC plot showing the corresponding genes (black dots) on meta probe set level. The loading plot shows which genes are responsible for clustering of the patients in the score plot. PCA, Principal components analysis; PC, principal component; TAV, tricuspid aortic valve; MMP, matrix metalloproteinase; TIMP, tissue inhibitors of metalloproteinase. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 459-466DOI: (10.1016/j.jtcvs.2011.08.043) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Immunohistochemistry analyses of MMP14 and MMP19 protein expression in the intima/medial layer of dilated and nondilated aortic specimens from TAV patients. A and B, MMP14 staining in dilated (A) and in nondilated aorta (B) (×20). C and D, Enlargements of MMP14 and von Willebrand factor (endothelial cells) staining, respectively, in consecutive sections of dilated aorta. E and F, MMP19 staining in dilated (E) and nondilated aorta (F) (×20). G-J, Enlargements of MMP19 (G, I) and von Willebrand factor (H, J) staining in consecutive sections of dilated (G, H) and nondilated aorta (I, J). K and L, CD68 staining (inflammatory cells) in dilated aorta (K) and α-actin staining (smooth muscle cells) (L) (×20). TAV, Tricuspid aortic valve; MMP, matrix metalloproteinase; TIMP, tissue inhibitors of metalloproteinase. The Journal of Thoracic and Cardiovascular Surgery 2012 144, 459-466DOI: (10.1016/j.jtcvs.2011.08.043) Copyright © 2012 The American Association for Thoracic Surgery Terms and Conditions