Analgesia and pulmonary function after lung surgery: is a single intercostal nerve block plus patient-controlled intravenous morphine as effective as.

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Presentation transcript:

Analgesia and pulmonary function after lung surgery: is a single intercostal nerve block plus patient-controlled intravenous morphine as effective as patient-controlled epidural anaesthesia? A randomized non-inferiority clinical trial  R. Meierhenrich, D. Hock, S. Kühn, E. Baltes, B. Muehling, R. Muche, M. Georgieff, G. Gorsewski  British Journal of Anaesthesia  Volume 106, Issue 4, Pages 580-589 (April 2011) DOI: 10.1093/bja/aeq418 Copyright © 2011 The Author(s) Terms and Conditions

Fig 1 Participant flow. EDA, epidural anaesthesia; POD, postoperative day. British Journal of Anaesthesia 2011 106, 580-589DOI: (10.1093/bja/aeq418) Copyright © 2011 The Author(s) Terms and Conditions

Fig 2 Pain course at rest (a), on coughing (b), and ‘maximum pain experienced since last questioning’ (c). Data given as median and 95% confidential interval of the median. *P<0.05; **P<0.01: comparison between the epidural and intercostal groups (Mann–Whitney rank sum test). NRS, numeric rating scale; POD1, POD2, POD3, and POD 4, first, second, third, and fourth postoperative day. British Journal of Anaesthesia 2011 106, 580-589DOI: (10.1093/bja/aeq418) Copyright © 2011 The Author(s) Terms and Conditions

Fig 3 Median treatment differences for NRS scores at rest on the first postoperative day. Error bars indicate two-sided 95% confidence intervals. Δ, margin of non-inferiority. Non-tinted area indicates zone of inferiority. NRS, numeric rating scale. British Journal of Anaesthesia 2011 106, 580-589DOI: (10.1093/bja/aeq418) Copyright © 2011 The Author(s) Terms and Conditions

Fig 4 Time course of pulmonary function: IVC (a), FVC (b), PEFR (c), and FEV1 (d). The median, 5% percentile, 95% percentile, and inter-quartile range (box) are shown. P-value, comparison between the epidural and intercostal groups (Mann–Whitney rank-sum test). IVC, inspiratory vital capacity; FVC, forced vital capacity; PEFR, peak expiratory flow rate; FEV1, forced expiratory volume 1; POD1, POD2, POD3, and POD 4, first, second, third, and fourth postoperative day. British Journal of Anaesthesia 2011 106, 580-589DOI: (10.1093/bja/aeq418) Copyright © 2011 The Author(s) Terms and Conditions