Volume 74, Issue 11, Pages (December 2008)

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Volume 74, Issue 11, Pages 1373-1375 (December 2008) Regulation of the Na+-Cl− cotransporter by dietary NaCl: a role for WNKs, SPAK, OSR1, and aldosterone Volker Vallon Kidney International Volume 74, Issue 11, Pages 1373-1375 (December 2008) DOI: 10.1038/ki.2008.477 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Model for the activation of NCC by increasing membrane expression and phosphorylation in the distal convoluted tubule (DCT). Effects are stimulatory (green arrows) or inhibitory (red breaks). In addition, a cell of the late DCT (DCT2)/connecting tubule (CNT) is shown to illustrate the indirect effect of inhibition of NCC-mediated Na+ reabsorption by high K+ intake on ROMK- and BK channel–mediated K+ excretion. Ang II, angiotensin II. Kidney International 2008 74, 1373-1375DOI: (10.1038/ki.2008.477) Copyright © 2008 International Society of Nephrology Terms and Conditions