Ulrich M. Zissler, PhD, Moritz Ulrich, Constanze A

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Biomatrix for upper and lower airway biomarkers in patients with allergic asthma Ulrich M. Zissler, PhD, Moritz Ulrich, Constanze A. Jakwerth, PhD, Sandra Rothkirch, MD, Ferdinand Guerth, MEng, Markus Weckmann, PhD, Matthias Schiemann, PhD, Bernhard Haller, PhD, Carsten B. Schmidt-Weber, PhD, Adam M. Chaker, MD Journal of Allergy and Clinical Immunology Volume 142, Issue 6, Pages 1980-1983 (December 2018) DOI: 10.1016/j.jaci.2018.07.027 Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Biomarker grids reflecting correlations between upper and lower airways cytokine levels. Intraorgan correlations for upper (A) and lower (B) airways and interorgan correlations (C) were depicted by using respective correlation coefficients (r) from negative (dark blue) to positive (red) values. Intraorgan correlations seemed to be predominantly strong, whereas interorgan relations were most visible by using nasal and sputum IL-24 measurements. G-CSF, Granulocyte colony-stimulating factor; TSLP, thymic stromal lymphopoietin. Journal of Allergy and Clinical Immunology 2018 142, 1980-1983DOI: (10.1016/j.jaci.2018.07.027) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Airway cytokines and cell populations. A-C, Although numbers of B lymphocytes and natural killer cells were upregulated in asthmatic patients during the grass pollen season, in Treg cells there was only a difference between patients and healthy control subjects. D-G, Type 2 cytokines were differentially regulated in asthmatic patients out of the grass pollen season, as well as in the grass pollen season. H-J, Positive correlations were visible for B-cell counts and sputum IL-13 and IL-10 levels, respectively, whereas a strong negative correlation was seen for sputum periostin levels and Treg cell counts. AiS, Asthmatic patients in the grass pollen season; AoS, asthmatic patients out of the grass pollen season; HC, healthy control subjects. Journal of Allergy and Clinical Immunology 2018 142, 1980-1983DOI: (10.1016/j.jaci.2018.07.027) Copyright © 2018 American Academy of Allergy, Asthma & Immunology Terms and Conditions