Excess Cancer Mortality in Six Dutch Pedigrees with the Familial Atypical Multiple Mole- Melanoma Syndrome from 1830 to 1994  Elysée T.M. Hille, Erik van Duijn, Nelleke A. Gruis, Frits R. Rosendaal, Wilma Bergman  Journal of Investigative Dermatology  Volume 110, Issue 5, Pages 788-792 (May 1998) DOI: 10.1046/j.1523-1747.1998.00185.x Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Excess mortality is present in most families. SMR with 95%CI, per FAMMM family from 1850 till 1994, ≥ 20 y of age. Journal of Investigative Dermatology 1998 110, 788-792DOI: (10.1046/j.1523-1747.1998.00185.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 The SMR is rising over calendar time. SMR with 95% CI, in FAMMM families according to calendar periods, ≥ 20 y of age. Journal of Investigative Dermatology 1998 110, 788-792DOI: (10.1046/j.1523-1747.1998.00185.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Excess mortality is confined to age groups 40–70 y. SMR with 95%CI, in FAMMM families according to age groups from 1850 till 1994. Journal of Investigative Dermatology 1998 110, 788-792DOI: (10.1046/j.1523-1747.1998.00185.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions