Fraser D. Rubens, MD, MS, Gilbert Lavalee, Marc A

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Presentation transcript:

Delayed Thrombin Generation With Hirudin Anticoagulation During Prolonged Cardiopulmonary Bypass Fraser D. Rubens, MD, MS, Gilbert Lavalee, Marc A. Ruel, MD, MPH, Thierry Mesana, MD, PhD, Michael Bourke, MD The Annals of Thoracic Surgery Volume 79, Issue 1, Pages 334-336 (January 2005) DOI: 10.1016/S0003-4975(03)01658-8

Fig 1 Effect of recombinant hirudin (lepirudin) on measured hirudin levels, as well as thrombin generation and activity during a case of prolonged cardiopulmonary bypass (CPB). Diamonds = hirudin (μg/mL); squares = TAT (μg/L); triangles = F1.2 (nmol/L). (TAT = thrombin antithrombin III; F1.2 = prothrombin fragment 1.2.) The Annals of Thoracic Surgery 2005 79, 334-336DOI: (10.1016/S0003-4975(03)01658-8)