Licensing PPARγ to Work in Macrophages

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Licensing PPARγ to Work in Macrophages Claudio J. Villanueva, Peter Tontonoz  Immunity  Volume 33, Issue 5, Pages 647-649 (November 2010) DOI: 10.1016/j.immuni.2010.11.017 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 IL-4 Facilitates PPARγ-Dependent Gene Expression through STAT6 Signaling In macrophages, PPARγ binds to the adipocyte PPAR response element (AdipoPPRE) as well as the macrophage PPAR response element (MacPPRE) in the Fabp4 gene (encoding aP2). Maximal PPARγ activity and expression of aP2 is dependent on STAT6 binding to a STAT6 response element (S6RE) adjacent to the MacPPRE. Immunity 2010 33, 647-649DOI: (10.1016/j.immuni.2010.11.017) Copyright © 2010 Elsevier Inc. Terms and Conditions

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