Sensitivity and specificity plots of human epididymis protein 4 (HE4) (A and B, respectively) and carbohydrate antigen 125 (CA-125) (C and D, respectively) determination in the diagnosis of ovarian cancer. Sensitivity and specificity plots of human epididymis protein 4 (HE4) (A and B, respectively) and carbohydrate antigen 125 (CA-125) (C and D, respectively) determination in the diagnosis of ovarian cancer. Simona Ferraro et al. J Clin Pathol 2013;66:273-281 Copyright © by the BMJ Publishing Group Ltd & Association of Clinical Pathologists. All rights reserved.