Nuclear accumulation of NFATc1 increases in Slc7a5-deficient osteoclasts. Nuclear accumulation of NFATc1 increases in Slc7a5-deficient osteoclasts. BMMs.

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Nuclear accumulation of NFATc1 increases in Slc7a5-deficient osteoclasts. Nuclear accumulation of NFATc1 increases in Slc7a5-deficient osteoclasts. BMMs from Slc7a5fl/fl mice were retrovirally infected with Cre recombinase and subsequently stimulated with RANKL, followed by immunoblotting and densitometric analysis of (A to C) NFATc1 abundance in the nucleus and whole-cell extracts and (D to I) phosphorylation of Erk1/2, JNK1/2, and p38. n = 4 mice per genotype. All data were analyzed by the two-way ANOVA with Bonferroni and/or Dunnett post hoc test. **P < 0.01, significantly different from the value obtained in control cells. Kakeru Ozaki et al., Sci. Signal. 2019;12:eaaw3921 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works