SP promotes corneal epithelial wound healing and restores corneal sensitivity in diabetic mice. SP promotes corneal epithelial wound healing and restores.

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SP promotes corneal epithelial wound healing and restores corneal sensitivity in diabetic mice. SP promotes corneal epithelial wound healing and restores corneal sensitivity in diabetic mice. Topical SP application for 7 days was used to examine the wound healing rate in diabetic corneal epithelium. The corneal epithelial wound was inflicted after 4 days of SP application and then stained with fluorescein sodium at 24, 48, and 72 h after the corneal epithelium scrape, with continuous daily SP administration in the Diabetic+SP group (A). Histogram of residual epithelial defect is presented as the percentage of the original wound (n = 6 per group) (B). Corneal sensitivity was measured in unanesthetized control, diabetic, and SP-treated diabetic mice after 4 days of topical application (n = 8 per group) (C). *P < 0.05. Lingling Yang et al. Diabetes 2014;63:4262-4274 ©2014 by American Diabetes Association