Induction of MHC-mismatched mixed chimerism depletes mature but not immature BM B cells by 60 days after HCT. Control and mixed chimeric NOD mice were.

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Induction of MHC-mismatched mixed chimerism depletes mature but not immature BM B cells by 60 days after HCT. Control and mixed chimeric NOD mice were euthanized 30, 45, and 60 days after HCT and analyzed for BM B-cell development. Induction of MHC-mismatched mixed chimerism depletes mature but not immature BM B cells by 60 days after HCT. Control and mixed chimeric NOD mice were euthanized 30, 45, and 60 days after HCT and analyzed for BM B-cell development. A: Representative pattern of gated CD45.1+B220+ BM B cells, showing B220 vs. CD43. B: Kinetics of percentages and yields (mean ± SE) of CD43+ pro-B cells and CD43− subsets (pre-B, immature, and mature) among CD45.1+B220+ BM B cells. n = 4–6 mice per group per time point. *P < 0.05; **P < 0.01; ***P < 0.001. C: Representative pattern of gated CD45.1+B220+CD43− BM B cells showing IgD vs. IgM. D: Kinetics of percentages and yields (mean ± SE) of IgMLoIgDLo (pre-B), IgMHiIgDLo (immature), and IgMLoIgDHi (mature) subsets among CD45.1+B220+CD43− BM B cells. n = 4–6 mice per group per time point. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001. Jeremy J. Racine et al. Diabetes 2014;63:2051-2062 ©2014 by American Diabetes Association