Therapeutic effect of IL-12/ms treatment on gonococcal infection depends on both IFN-γ and B cells. Therapeutic effect of IL-12/ms treatment on gonococcal.

Slides:

Advertisements

Similar presentations

A Novel Cancer Therapeutic Using Thrombospondin 1 in Dendritic Cells

Advertisements

Activation of NK cells during the early stage of allergic and fibrotic lung inflammation. Activation of NK cells during the early stage of allergic and.

In vivo selectivity of compound 6b.

Acid stability of the HA protein of clade

The NLRP12 Inflammasome Recognizes Yersinia pestis

Expression of IL-1α in goblet cells and their destruction during DSS-induced colitis. Expression of IL-1α in goblet cells and their destruction during.

Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. AT-3ovadim.

Treatment of SFTSV-infected IFNAR−/− mice with T-705 or ribavirin.

C1ORF106 contributes to intestinal epithelial barrier function.

Survival of mice after infection with M

Maraba treatment sensitizes 4T1 tumors to immune checkpoint blockade

IL-6 is dispensable for the suppressive activity of MDSC on primary CD4+ T-cell activation. IL-6 is dispensable for the suppressive activity of MDSC on.

IFN-γ antagonizes TGF-β in vivo.

Fig. 3 Biological function of TG2 and the interaction with MT-2.

IFN-γ activates the fibrinolytic system.

Peritumoral injections of poly(I:C) induce type I IFN–dependent cytotoxic immunity and delay the growth of primary and transplanted Hgf-Cdk4R24C melanomas.

Volume 36, Issue 3, Pages (March 2012)

Dibutyryl cAMP does not rescue staurosporine-induced filamentation of a cyr1Δ/cyr1Δ mutant. Dibutyryl cAMP does not rescue staurosporine-induced filamentation.

Volume 22, Issue 12, Pages (March 2018)

Antitumor effect of local cancer immunotherapy treatment toward distant B16F10 tumors. Antitumor effect of local cancer immunotherapy treatment toward.

IL-21 is involved in the pathogenesis of EAM

Categorization of the top 200 N

SEM images of S. aureus ATCC cells left untreated (A) or treated with polymyxin B (PMB; 99.5 mg/liter) (B), FADDI-019 (1× MIC) (C), FADDI-019 (4×

Histological changes in mouse colons after DSS treatment.

Fig. 4. Improved tumor response to docetaxel in TNBC and trastuzumab in HER2-amplified PDX models with the addition of S Improved tumor response.

The pho4Δ mutant is less virulent than the WT strain in intranasal (A to C) and intravenous (D to F) models of cryptococcosis. The pho4Δ mutant is less.

Volume 19, Issue 5, Pages (November 2003)

T-705 treatment of SFTSV-infected IFNAR−/− mice through oral administration. T-705 treatment of SFTSV-infected IFNAR−/− mice through oral administration.

TLR9 deficiency promotes aberrant T cell and myeloid dendritic cell (DC) phenotype in imiquimod-induced autoimmunity. TLR9 deficiency promotes aberrant.

Increased resistance of GPR55-deficient mice to indomethacin-induced intestinal permeability. Increased resistance of GPR55-deficient mice to indomethacin-induced.

C. jejuni flaC mutants induce increased cell activation in human and chicken cells. C. jejuni flaC mutants induce increased cell activation in human and.

Fig. 2. Exposure of both TCR and CAR antigens diminishes efficacy of CAR8 but not CAR4 cells. Exposure of both TCR and CAR antigens diminishes efficacy.

Deficiency of TLR9 promotes more severe renal inflammation in imiquimod-induced autoimmunity. Deficiency of TLR9 promotes more severe renal inflammation.

Abilities of C. muridarum with or without mutations in tc0668 and/or tc0237 to spread to the GI tract and induce hydrosalpinx in the genital tract. Abilities.

Side-view and apical-view projections of mutant and validation strain biofilms. Side-view and apical-view projections of mutant and validation strain biofilms.

MP cells can mediate resistance in infectious models that induce TH1-type immunity. MP cells can mediate resistance in infectious models that induce TH1-type.

Figure 3 TRIF deficiency abrogates the immunomodulatory effects of glatiramer acetate treatment on cytokines and experimental autoimmune encephalomyelitis.

IL-27 contributes to IR expression by lung T cells during toxoplasmosis. IL-27 contributes to IR expression by lung T cells during toxoplasmosis. (A) Il27p28-GFP.

Dynamic ranges of anti-PnPS IgG Reference standard serum 007sp for each of 13 serotypes. Dynamic ranges of anti-PnPS IgG Reference standard serum 007sp.

IFN-γ antagonizes TGF-β in vivo.

Fold changes in CgA, MUC2, PCNA, SOX9, and villin mRNA levels in IECs of deficient-diet HIFM/HRV-infected versus deficient-diet HRV-infected pigs (A) and.

Growth of Salmonella and E. coli in egg white.

Rab27a promotes migration of neutrophils in vivo and in vitro.

Administration of necroptosis-targeting AAVs in conjunction within vivo promotes durable tumor clearance. Administration of necroptosis-targeting AAVs.

Protective effects of cysteine protease inhibitor Z-FA-FMK and E64d in SMNΔ7 mice. Protective effects of cysteine protease inhibitor Z-FA-FMK and E64d.

NK cell function of spleen MNCs (A) and NK cell frequencies in the ileum, duodenum, and spleen (B) of protein-deficient and -sufficient HIFM/HRV-infected.

B cell development in wild-type and Syk-AQL mice.

Measurement of insulin release from islets evoked by glucose, diazoxide, and high K+. Measurement of insulin release from islets evoked by glucose, diazoxide,

IFN-γ activates the fibrinolytic system.

Treatment of G. mellonella-infected larvae with norfloxacin or norfloxacin plus TPGS in combination with the wild type or ΔbcnA mutant. Treatment of G.

Prime and boosts with PBK001 vaccine provided 100% protection with low bacterial burden in organs. Prime and boosts with PBK001 vaccine provided 100% protection.

SAM transport by Gap4 in S. cerevisiae cells.

A. baumannii activates the autophagosome-lysosome system.

Fold changes in CgA, MUC2, PCNA, SOX9, and villin mRNA levels in IECs of deficient- versus sufficient-diet HIFM/HRV-infected pigs (A), of deficient- versus.

Intranasal immunization of mice with S

In vivo assessment of synergistic activity of MV-CEA and RT in a U87 s

Lamellarin D induces cell death through a Fas-independent pathway.

A, one-step viral growth curves: RT treatment increased the virus yield in MV-CEA–treated U87 cells by up to 2 log as compared with MV-CEA infection only.

A Novel Cancer Therapeutic Using Thrombospondin 1 in Dendritic Cells

Influenza vaccine enhances NK cell function through IFN-α.

B. fragilis utilizes TLR2 signaling for its protective role against the development of colitis-associated cancer in mice. B. fragilis utilizes TLR2 signaling.

TLR9 deficiency leads to more severe impairment of endothelium-dependent vasorelaxation and promotes aberrant B cell phenotype in imiquimod-induced autoimmunity.

Antibody-mediated blockade of the immune-inhibitory PD-1–PD-L1 signaling pathway prolongs survival in poly(I:C)-treated mice. Antibody-mediated blockade.

Treatment with a Ron inhibitor significantly reduces metastatic outgrowth. Treatment with a Ron inhibitor significantly reduces metastatic outgrowth. A,

Pseudomonas PIV enhances pneumococcal pneumonia and bacteremia in C57BL/6 mice. Pseudomonas PIV enhances pneumococcal pneumonia and bacteremia in C57BL/6.

Fig. 5 In vivo autologous self-targeting efficacy of DR-KO tumor cells co-engineered with a secretable DRL and a suicide system. In vivo autologous self-targeting.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

GBM cells infected in vitro with HCMV divide less often than uninfected cells do. GBM cells infected in vitro with HCMV divide less often than uninfected.

GBM 112 and GBM 144 cells infected in vitro with HCMV resist growth inhibition by temozolomide. GBM 112 and GBM 144 cells infected in vitro with HCMV resist.

Confirmation of spliced RNA in cells transfected with a wild-type or Pol(−) MR766 ZIKV plasmid. Confirmation of spliced RNA in cells transfected with a.

Presentation transcript:

Therapeutic effect of IL-12/ms treatment on gonococcal infection depends on both IFN-γ and B cells. Therapeutic effect of IL-12/ms treatment on gonococcal infection depends on both IFN-γ and B cells. (A) Accelerated clearance of N. gonorrhoeae by treatment with IL-12/ms is abrogated in IFN-γ-deficient (IFN-γ-KO) mice compared to wild-type mice. (Left and middle) Recovery (mean CFU ± SEM; n = 8) of N. gonorrhoeae on vaginal swabs after infection with strain FA1090 in wild-type (left) and IFN-γ-KO (middle) mice. Curves are significantly different (P < 0.01 by ANOVA) comparing treatment with IL-12/ms versus blank ms for wild-type (WT) mice. Curves are not significantly different (NS) for IFN-γ-KO mice. (Right) Percentage of mice remaining infected at each time point. Curves are significantly different (P < 0.005 by Kaplan-Meier analysis) comparing treatment with IL-12/ms versus blank ms for wild-type mice. Curves are not significantly different (NS) for IFN-γ-KO mice. (B) Accelerated clearance of N. gonorrhoeae by treatment with IL-12/ms is abrogated in B-cell-deficient (µMT) mice compared to wild-type mice. (Left and middle) Recovery (mean CFU ± SEM; n = 8) of N. gonorrhoeae on vaginal swabs after infection with FA1090 in wild-type (left) and µMT (middle) mice. Curves are significantly different (P < 0.01 by ANOVA) comparing treatment with IL-12/ms versus blank ms for wild-type mice. Curves are not significantly different (NS) for µMT mice. (Right) Percentage of mice remaining infected at each time point. Curves are significantly different (P < 0.002 by Kaplan-Meier analysis) comparing treatment with IL-12/ms versus blank ms for wild-type mice. Curves are not significantly different (NS) for µMT mice. (C and D) Vaginal (C) and serum (D) antibody responses induced by IL-12/ms treatment are diminished in IFN-γ-deficient (IFN-γ-KO) compared to wild-type mice. Values that are significantly different (by Student’s t test) for mice treated with IL-12/ms from values for mice treated with blank ms are indicated as follows: *, P < 0.01; #, P < 0.05. (E) IFN-γ responses induced by treatment with IL-12/ms are maintained in B-cell-deficient (µMT) mice. Values that are significantly different (P < 0.01 by Student’s t test) comparing treatment with IL-12/ms versus blank ms in both wild-type and µMT mice are indicated by an asterisk. Yingru Liu et al. mSphere 2018; doi:10.1128/mSphere.00421-17