A Synaptic Basis for GLP-1 Action in the Brain

Slides:

Advertisements

Similar presentations

The Neurobiology of Decision: Consensus and Controversy Joseph W. Kable, Paul W. Glimcher Neuron Volume 63, Issue 6, Pages (September 2009) DOI:

Advertisements

Treating the Developing versus Developed Brain: Translating Preclinical Mouse and Human Studies B.J. Casey, Charles E. Glatt, Francis S. Lee Neuron Volume.

Preference Distributions of Primary Motor Cortex Neurons Reflect Control Solutions Optimized for Limb Biomechanics Timothy P. Lillicrap, Stephen H. Scott.

The Pathobiology of Vascular Dementia Costantino Iadecola Neuron Volume 80, Issue 4, Pages (November 2013) DOI: /j.neuron Copyright.

Decision Making as a Window on Cognition Michael N. Shadlen, Roozbeh Kiani Neuron Volume 80, Issue 3, Pages (October 2013) DOI: /j.neuron

Contour Saliency in Primary Visual Cortex Wu Li, Valentin Piëch, Charles D. Gilbert Neuron Volume 50, Issue 6, Pages (June 2006) DOI: /j.neuron

AMPA Receptor Signaling through BRAG2 and Arf6 Critical for Long-Term Synaptic Depression Ralf Scholz, Sven Berberich, Louisa Rathgeber, Alexander Kolleker,

GDE2 Regulates Subtype-Specific Motor Neuron Generation through Inhibition of Notch Signaling Priyanka Sabharwal, Changhee Lee, Sungjin Park, Meenakshi.

Neuronal Cell Types and Connectivity: Lessons from the Retina H. Sebastian Seung, Uygar Sümbül Neuron Volume 83, Issue 6, Pages (September 2014)

Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease Nobutaka Hirokawa, Shinsuke Niwa, Yosuke Tanaka.

Pyramidal Neurons Grow Up and Change Their Mind Gord Fishell, Carina Hanashima Neuron Volume 57, Issue 3, Pages (February 2008) DOI: /j.neuron

Hippocampal Activity Patterns Carry Information about Objects in Temporal Context Liang-Tien Hsieh, Matthias J. Gruber, Lucas J. Jenkins, Charan Ranganath.

Mechanisms of Age-Related Macular Degeneration Jayakrishna Ambati, Benjamin J. Fowler Neuron Volume 75, Issue 1, Pages (July 2012) DOI: /j.neuron

Adaptation to Natural Binocular Disparities in Primate V1 Explained by a Generalized Energy Model Ralf M. Haefner, Bruce G. Cumming Neuron Volume 57, Issue.

Reading the Book of Memory: Sparse Sampling versus Dense Mapping of Connectomes H. Sebastian Seung Neuron Volume 62, Issue 1, Pages (April 2009)

Leptin-melanocortin system of energy balance

C. The arcuate neurons shown in part B project to multiple regions of the hypothalamus. The paraventricular nucleus (PVN) is a convergence zone for many.

P.W. Kalivas, N. Volkow, J. Seamans Neuron

Nat. Rev. Endocrinol. doi: /nrendo

A Molecular Code for Imprinting Drug-Cue Associations

Synaptic Physiology: Illuminating the Road Ahead

Volume 60, Issue 3, Pages (November 2008)

Calcium Signaling and the Control of Dendritic Development

Calcium Signals Control Wnt-Dependent Dendrite Growth

Glia, Adenosine, and Sleep

Identification of the Synthetic Pathway Producing the Endocannabinoid that Mediates the Bulk of Retrograde Signaling in the Brain Aaron R. Best, Wade.

Volume 96, Issue 4, Pages e5 (November 2017)

Kv1.1 Takes a deTOR from the Axon to the Dendrite

Letting Go of JuNK by Disassembly of Adhesive Complexes

Emerging Global Initiatives in Neurogenetics: The Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) Consortium Carrie E. Bearden, Paul M.

Silent Synapses Sit and Wait for a Better Day

Dissonant Synapses Shall Be Punished

RIPping off GABA Release in Hypothalamic Circuits Causes Obesity

Pausing to Regroup: Thalamic Gating of Cortico-Basal Ganglia Networks

There's More Than One Way to Scale a Synapse

Applying the Brakes: When to Stop Eating

Volume 68, Issue 2, Pages (October 2010)

Volume 55, Issue 3, Pages (August 2007)

[Br]eaking FAt Cell Volume 159, Issue 2, Pages (October 2014)

Julien Courchet, Franck Polleux Neuron

Maribel Rios Trends in Neurosciences

Learning about Synaptic GluA3

Volume 32, Issue 3, Pages (November 2001)

Emerging Global Initiatives in Neurogenetics: The Enhancing Neuroimaging Genetics through Meta-analysis (ENIGMA) Consortium Carrie E. Bearden, Paul M.

Synaptic Plasticity of Feeding Circuits: Hormones and Hysteresis

K+ Channel Regulation of Multicompartmental Signal Integration

Aligning a Synapse Neuron

Curbing Fear by Axonal Oxytocin Release in the Amygdala

Ménage à Trio during BMP-Mediated Retrograde Signaling at the NMJ

Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect

The Two Sides of Hippocampal Mossy Fiber Plasticity

Volume 91, Issue 6, Pages (September 2016)

Brain Canada: One Brain One Community

Location, Location, Location: Contrasting Roles of Synaptic and Extrasynaptic NMDA Receptors in Huntington's Disease Michael S. Levine, Carlos Cepeda,

The Hormonal Control of Food Intake

Angelman Syndrome: Finding the Lost Arc

Treating obesity: Does antagonism of NPY fit the bill?

Dorothy P. Schafer, Beth Stevens Immunity

Dawn H. Loh, Takashi Kudo, Christopher S. Colwell Neuron

Thoughts for Food: Brain Mechanisms and Peripheral Energy Balance

Aya Matsui, Veronica A. Alvarez Neuron

David C. Spanswick, Stephanie E. Simonds, Michael A. Cowley

Giuseppe Condomitti, Joris de Wit Developmental Cell

GABA Keeps Up an Appetite for Life

The Cost of Brain Diseases: A Burden or a Challenge?

Brain Canada: One Brain One Community

Kevin J. Mastro, Aryn H. Gittis Neuron

Of Mice and MEN Stephen R.J Salton, Seung Hahm, Tooru M Mizuno Neuron

David Hubel and Torsten Wiesel

Biological Functions of Activity-Dependent Transcription Revealed

Presentation transcript:

A Synaptic Basis for GLP-1 Action in the Brain Sandrine Lefort, Matthias H. Tschöp, Cristina García-Cáceres Neuron Volume 96, Issue 4, Pages 713-715 (November 2017) DOI: 10.1016/j.neuron.2017.10.034 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Hindbrain GLP-1 Signaling to PVN Neurons Reduces Food Intake by Regulating AMPAR Trafficking (A) Pathways connecting glucagon-like peptide-1 (GLP-1)-producing neurons in the nucleus tractus solitarius (NTSGCG) with neuronal populations from the paraventricular nucleus of the hypothalamus (PVN). CRH, corticotropin-releasing hormone; OXT, oxytocin; AVP, arginine-vasopressin. (B) Enhanced AMPAR trafficking and excitability upon GLP-1R signaling on postsynaptic PVNCRH neurons lead to a decrease in food intake. This effect is independent of presynaptic glutamate release from NTSGCG neurons. (C) Impact of genetic disruption of GLP-1R expression on postsynaptic AMPA-mediated current in PVNCRH neurons. A global, postnatal GLP-1R knockout in PVN neurons induces obesity. Neuron 2017 96, 713-715DOI: (10.1016/j.neuron.2017.10.034) Copyright © 2017 Elsevier Inc. Terms and Conditions