Male FBN-ARO-KO mice exhibit cognitive defects but normal locomotor activity and anxiety levels. Male FBN-ARO-KO mice exhibit cognitive defects but normal.

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Male FBN-ARO-KO mice exhibit cognitive defects but normal locomotor activity and anxiety levels. Male FBN-ARO-KO mice exhibit cognitive defects but normal locomotor activity and anxiety levels. A, Representative tracking plots of FLOX (Aa) and FBN-ARO-KO (Ab) mice on the third day of the Barnes maze training trial. Escape latency (Ac) and escape velocity (Ad) were also recorded and statistical data are shown. B, Representative tracking plots of FLOX (Ba) and FBN-ARO-KO (Bb) mice on the probe trial day. Quadrant occupancy (Bc) and exploring errors (Bd) made during probe trial stage were recorded and statistically analyzed. C, The novel object recognition test (NORT) was performed to evaluate recognition memory. Representative tracking plots of the indicated mice on NORT choice day are shown in Ca and Cb. Exploration time (Cc) and discrimination index (Cd) were statistically analyzed afterward. D, Fear acquisition curve during conditioning test was analyzed (Da). Cued freezing rate (Db) and contextual freezing rate (Dc) were assayed 24 h after fear conditioning to test cued fear memory and contextual fear memory, respectively. E, The forced-swimming test was conducted to evaluate the depression level. Immobility time during forced swimming was recorded as an index of depression. F, Rearing times (Fa), travel distance (Fb), grooming times (Fc), and time in center zone (Fd) were determined in the open-field test to assess locomotor function (Fa, Fb) and anxiety level (Fc, Fd). Data are shown as means ± SEM. n = 8. *p < 0.05 versus FLOX group; #p < 0.05 versus familiar object. Yujiao Lu et al. J. Neurosci. 2019;39:2792-2809 ©2019 by Society for Neuroscience