Serum levels of Clara cell secretory protein, asthma, and lung function in the adult general population Marta Rava, PhD, Lluisa Tares, Iris Lavi, PhD,

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Serum levels of Clara cell secretory protein, asthma, and lung function in the adult general population Marta Rava, PhD, Lluisa Tares, Iris Lavi, PhD, Esther Barreiro, MD, PhD, Jan-Paul Zock, PhD, Anna Ferrer, MD, Nerea Muniozguren, MD, Rachel Nadif, PhD, Lucia Cazzoletti, MS, Francine Kauffmann, MD, Josep M. Anto, MD, PhD, Stefano Guerra, MD, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 1, Pages 230-232.e6 (July 2013) DOI: 10.1016/j.jaci.2013.01.023 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Mean lung function parameters and 95% CI by quartiles of serum CC-16 levels (μg/L). Asterisks represent P values obtained by comparing the mean lung function level for each quartile of the serum CC-16 level with the first quartile as reference (*P < .10, **P < .05, and ***P < .001). Journal of Allergy and Clinical Immunology 2013 132, 230-232.e6DOI: (10.1016/j.jaci.2013.01.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Prevalence of asthma and airflow limitation by quartiles of serum CC-16 levels. Asterisks represent P values obtained by comparing the unadjusted odds ratio of having the outcome for each quartile of the serum CC-16 level, using the first quartile as reference. LLN, Lower limit of normal. *P < .10, **P < .05, and ***P <.001. Journal of Allergy and Clinical Immunology 2013 132, 230-232.e6DOI: (10.1016/j.jaci.2013.01.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Adjusted regression coefficients (beta) and 95% CI for the association between serum CC-16 levels and lung function parameters, estimated through a multivariate linear regression model, stratified by asthma status. The P values refer to the interaction between asthma status and serum CC-16 levels. Journal of Allergy and Clinical Immunology 2013 132, 230-232.e6DOI: (10.1016/j.jaci.2013.01.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Adjusted regression coefficients (beta) and 95% CI for the association between serum CC-16 levels and lung function parameters, estimated through a multivariate linear regression model, stratified by smoking status. The P values refer to the interaction between smoking status and serum CC-16 levels. Journal of Allergy and Clinical Immunology 2013 132, 230-232.e6DOI: (10.1016/j.jaci.2013.01.023) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions